Table 3 Thyroid disease and diabetes mellitus screening measures among patients with and without celiac disease
From: Prevalence of markers of beta cell autoimmunity and thyroid disease in children with coeliac disease
Healthy controls (n = 200) | Mean of positive antibodies in healthy controls | Celiac disease (n = 95) | Mean of positive antibodies in patients with celiac disease | Relative between-group difference, % (95% CI) | Spearman’s rank correlation between t-Transglutaminase & antibodies | |
|---|---|---|---|---|---|---|
Thyroid disease, mean (SD) | ||||||
TSH, mU/l | 1.79 (1.66) | 1.90 (1.92) | 6.16 (-8.94 to 22.78) | 0.085; p = 0.23 | ||
TRAb, U/l | 1.83 (1.27) | 3.6 | 2.00 (1.33) | 5.6 | 9.50 (2.86 to 16.56) | 0.255; p<0.001 |
Anti-Tg, U/l | 10.02 (2.34) | 621 | 8.99 (2.24) | 174 | -10.26 (-27.04 to 10.39) | -0.163; p = 0.01 |
Anti-TPO, U/l | 2.17 (2.45) | 185 | 2.32 (2.74) | - | 6.69 (-15.29 to 34.39) | -0.036; p = 0.59 |
Diabetes mellitus, mean (SD) | ||||||
Anti-GAD, U/ml | 5.14 (1.25) | 205.2 | 5.22 (1.43) | 82.2 | 1.60 (-5.13 to 8.80) | 0.026; p = 0.71 |
Anti-ZnT8, U/ml | 10.55 (1.35) | 52.5 | 10.97 (1.75) | 343 | 4.04 (-5.95 to 15.08) | -0.023; p = 0.74 |
Anti-IA2, U/ml | 15.29 (1.19) | 62.4 | 15.56 (1.42) | 432 | 1.76 (-4.34 to 8.24) | 0.075; p = 0.276 |
Anti-insulin, U/ml | 3.41 (1.32) | 17.9 | 3.38 (1.41) | 56 | -0.75 (-7.92 to 6.98) | -0.020 ; p = 0.76 |