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Table 2 Baseline comparison of ARC and non-ARC

From: Age-associated augmented renal clearance and low BMI trigger suboptimal vancomycin trough concentrations in children with haematologic diseases: data of 1453 paediatric patients from 2017 to 2022

Characteristics a

Median (P25, P75) / No. (%)

χ 2 /t/Z

value

ARC

Non-ARC

Number

1158(79.70%)

295(20.3%)

  

Age (yrs)

6.4(3.7, 10.325)

8.4(3.8, 11.3)

-2.826

0.005

Sex (male)

678(58.5%)

189(64.1%)

2.975

0.085

Weight (kg)

21(15, 32.7)

25.4(15, 41)

-3.42

0.001

BMI (kg/m2)

15.73(14.36, 17.47)

16.82(14.87, 19.32)

-5.278

0.000

BUN (mmol/L)

3.54(2.64, 4.68)

4.4(3.34, 5.6)

-7.609

0.000

SCR (µmol/L)

23.1(18.2, 28.7)

41(33.4, 50.9)

-21.6

0.000

WBC(*10^9/L)

0.62(0.05, 2.27)

1.25(0.27, 3.12)

-4.863

0.000

NE(*10^9/L)

0.07(0.00, 0.86)

0.19(0.01, 1.14)

-4.05

0.000

Neutropenia

807(69.7%)

186(63.1%)

4.788

0.029

Sepsis

948(81.9%)

244(82.7%)

0.114

0.735

eGFR

182.259(157.128, 217.942)

111.948(98.145, 121.617)

-26.549

0.000

  1. a BMI Body Mass Index, BUN Blood urea nitrogen, SCR Serum creatinine, WBC White blood cells, NE Neutrophil, eGFR Estimate glomerular filtration rate