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Table 1 Clinical characteristics of 1453 patients

From: Age-associated augmented renal clearance and low BMI trigger suboptimal vancomycin trough concentrations in children with haematologic diseases: data of 1453 paediatric patients from 2017 to 2022

 

Value

 

Characteristics a

No. (%)

Median (P25, P75) /Average (SD)

Patients

1453

 

Infants (< 2yrs)

139(9.57%)

 

Children (2 to 12yrs)

1071(73.71%)

 

Adolescents (12 to 18yrs)

243(16.72%)

 

Samples

1453

 

Sex (male)

867(59.67%)

 

Age (yrs)

 

6.7(3.7, 10.7)

Weight (kg)

 

21.7(15, 34.5)

BMI (kg/m2)

 

15.91(14.42, 17.88)

ALB (g/L)

 

38.85(0.11)

ALT (U/L)

 

25.1(14.6, 45.8)

AST (U/L)

 

24.6(17, 36.75)

ALP (U/L)

 

122(92, 163.05)

GTT (U/L)

 

24.2(15.5, 50.55)

TBIL (µmol/L)

 

10.7(7.30, 15, 71)

DBIL (µmol/L)

 

4.24(2.82, 6.63)

IBIL (µmol/L)

 

6.3(4.32, 9.14)

BUN (mmol/L)

 

3.69(2.73, 4.85)

SCR (µmol/L)

 

25.4(19.65, 33.7)

LDH (U/L)

 

220.6(174, 310.95)

WBC (*10^9/L)

 

0.75(0.07, 2.47)

NE (*10^9/L)

 

0.1(0.00, 0.95)

HLB (g/L)

 

78(69, 89)

PLT (*10^9/L)

 

44(24, 86)

eGFR

 

169.85(137.11, 207.31)

Hematologic malignancy type

 Acute lymphoblastic leukemia

594(40.88%)

 

 Acute non-lymphocytic leukemia

444(30.56%)

 

 lymphoma

48(3.3%)

 

 Aplastic anemia

212(14.59%)

 

 other

155(10.67%)

 

 Vancomycin dose(mg/kg/day)

39.6(37.5, 42.36)

 

 Vancomycin trough concentration (mg/L)

5.3(3.5, 8.3)

 
  1. a BMI Body Mass Index, ALB Albumin, ALT Alanine transaminase, AST Aspartate transferase, ALP Alkaline phosphatase, GTT Glutamyl transpeptidase, TBIL Total bilirubin, DBIL Direct bilirubin, IBIL Indirect bilirubin, BUN Blood urea nitrogen, SCR Serum creatinine, LDH Lactic dehydrogenase, WBC White blood cells, NE Neutrophil, HLB Hemoglobin, PLT Blood platelet, eGFR estimate glomerular filtration rate