Table 3 Multivariable association of clinical and economic factors with overall survival, postrelapse overall survival, and event-free survival within 5 years of follow-up, based on Cox regression models
From: Prognostic factors for intermediate- or high-risk neuroblastomas in children in China
Characteristics | Events / n (%) | HR (95% CI) | P value |
|---|---|---|---|
Overall survival | 67/147(45.6) | ||
Risk group | 0.02 | ||
Intermediate-risk | 3/30(10.0) | 1 | |
High-risk | 64/117(54.7) | 1.200 (1.080 ~ 1.225) | |
Age Group | 0.021 | ||
≤ 18 months | 10/36(27.8) | 0.598 (0.387 ~ 0.924) | |
18 months – 4 years | 28/57(49.1) | 1 | |
> 4 years | 29/54(53.7) | 1.138 (0.829 ~ 1.625) | |
Efficacy of induction chemotherapy | 0.001 | ||
CR | 31/96 (66.2) | 1 | |
PR | 18/32 (56.3) | 1.490 (1.409 ~ 2.695) | |
PD | 16/17 (94.1) | 1.949 (1.490 ~ 7.112) | |
Post-relapse overall survival time | |||
Risk group | 0.011 | ||
Intermediate-risk | 2/3(66.7) | 1 | |
High-risk | 49/70(70.0) | 5.286 (3.828 ~ 6.897) | |
Date of diagnosis | 0.012 | ||
2006–2010 | 30/36(55.5) | 2.123 (1.486 ~ 3.215) | |
2011–2015 | 21/37(56.8) | 1 | |
Event-free survival | 76/147(51.7) | ||
Risk group | 0.001 | ||
Intermediate-risk | 4/30(13.3) | 1 | |
High-risk | 72/117(61.5) | 3.007 (1.245 ~ 4.527) | |