Table 2 Multivariable association of clinical and economic factors with overall survival, postrelapse overall survival, and event-free survival using Cox regression models
From: Prognostic factors for intermediate- or high-risk neuroblastomas in children in China
Characteristics | Events / n (%) | HR (95% CI) | P value |
|---|---|---|---|
Overall survival | 67/147(45.6) | 0.001 | |
Risk group | 0.043 | ||
Intermediate-risk | 3/30 (10.0) | 1 | |
High-risk | 64/117 (54.7) | 12.467 (11.029 ~ 12.951) | |
Efficacy of induction chemotherapy# | 0.001 | ||
CR | 31/96 (66.2) | 1 | |
PR | 18/32 (56.3) | 1.200 (1.475 ~ 2.509) | |
PD | 16/17 (94.1) | 1.924 (1.623 ~ 3.012) | |
Metastasis sites | 0.001 | ||
Others | 48/125(38.4) | 1 | |
Intracranial metastasis | 19/22(86.4) | 3.057 (0.941 ~ 4.892) | |
Post-relapse overall survival time | |||
Post-relapse OS | 51/73(69.9) | ||
Metastasis sites | 0.001 | ||
Intracranial metastasis | 15/16(93.8) | 2.140 (1.234 ~ 3.710) | |
Others | 36/57(63.2) | 1 | |
Risk group | 0.021 | ||
Intermediate-risk | 27/36(75.0) | 1 | |
High-risk | 24/37(64.9) | 1.279 (1.182 ~ 1.849) | |
Efficacy of induction chemotherapy# | |||
CR | 22/39(56.4) | 1 | 0.001 |
PR | 10/15(62.5) | 1.493 (1.095 ~ 2.513) | |
PD | 16/17(94.1) | 1.911 (1.183 ~ 6.511) | |
Event-free survival | 97/147(65.9) | ||
Relapse | 0.001 | ||
No | 25/74(33.8) | 1 | |
Yes | 72/73(98.6) | 2.173 (1.333 ~ 3.542) | |
Gender | 0.009 | ||
Male | 60/97(61.9) | 1 | |
Female | 37/50(74.0) | 3.007 (1.245 ~ 4.527) | |
Efficacy of induction chemotherapy | 0.046 | ||
CR | 53/96(55.2) | 1 | |
PR | 25/32(78.1) | 1.490 (1.399 ~ 2.312) | |
PD | 17/17(100.0) | 2.270 (2.138 ~ 3.270) | |