From: Impact of prematurity on long-stay paediatric intensive care unit admissions in England 2008-2018
Study population | Terma | Preterma | |||||||
---|---|---|---|---|---|---|---|---|---|
All preterm | Extreme preterm (<28 weeks) | ||||||||
Standard stay | Long-stay | Standard stay | Long-stay | p (long- stay: preterm vs term) | Standard stay | Long-stay | p (long-stay: extreme preterm vs term) | ||
Children, n (%) | 67,615 (100) | 34,457 (96.0) | 1,440 (4.0) | 15,443 (94.5) | 901 (5.5) | <0.001 | 3,339 (93.6) | 227 (6.4) | <0.001 |
Postmenstrual age at first admission, median weeks (IQR) | 42.3 (38.0 to 62.7) | 45.3 (40.0 to 70.0) | 41.3 (38.0 to 54.1) | 38.3 (35.0 to 48.4) | 38.3 (34.0 to 46.9) | <0.001 | 37.9 (29.3 to 47.4) | 40.1 (31.3 to 48.4) | <0.001 |
Female sex, n (%) | 28,477 (42.1) | 14,519 (42.1) | 652 (45.3) | 6,421 (41.6) | 368 (40.8) | 0.034 | 1,396 (41.8) | 88 (38.8) | 0.065 |
Cumulative PICU length of stay, median days (IQR) | 3.8 (1.7 to 8.0) | 3.7 (1.7 to 7.2) | 64.4 (43.0 to 104.9) | 4.5 (2.0 to 9.1) | 63.8 (43.5 to 102.3) | 0.635 | 4.7 (1.7 to 10.8) | 65.6 (44.0 to 103.8) | 0.816 |
Cumulative length of invasive ventilation, median days (IQR) | 3 (1 to 7) | 3 (1 to 6) | 46 (30 to 77.5) | 4 (1 to 7) | 45 (29 to 74) | 0.747 | 4 (1 to 9) | 48 (26 to 79) | 0.568 |
Transfer from neonatal unit on first PICU admission, n (%) | 12,528 (18.5) | 5,649 (16.4) | 432 (30.0) | 4,723 (30.6) | 467 (51.8) | <0.001 | 1,612 (48.3) | 144 (63.4) | <0.001 |
Diagnostic category of first PICU admission, n (%) | |||||||||
Cardiovascular | 23,455 (34.7) | 13,646 (39.6) | 742 (51.5) | 3,209 (20.8) | 265 (29.4) | <0.001 | 642 (19.2) | 37 (16.3) | <0.001 |
Respiratory | 20,394 (30.2) | 9,352 (27.1) | 345 (24.0) | 6,291 (40.7) | 336 (37.3) | 1,209 (36.2) | 118 (52.0) | ||
Neurological | 5,660 (8.4) | 3,012 (8.7) | 72 (5.0) | 904 (5.9) | 46 (5.1) | 190 (5.7) | 12 (5.3) | ||
Gastrointestinal | 5,359 (7.9) | 2,251 (6.5) | 64 (4.4) | 2,009 (13.0) | 90 (10.0) | 707 (21.2) | 33 (14.5) | ||
Infection | 3,954 (5.9) | 1,960 (5.7) | 44 (3.1) | 1,003 (6.5) | 39 (4.3) | 157 (4.7 | 10 (4.4) | ||
Other | 8,584 (12.7) | 4,157 (12.1) | 169 (11.7) | 1,982 (12.8) | 125 (13.9) | 423 (12.7) | 17 (7.5) | ||
Missing | 209 (0.3) | 79 (0.2) | 4 (0.3) | 45 (0.3) | 0 | 11 (0.3) | 0 | ||
PIM2 on first admission, median % (IQR) | 2.2 (1.0 to 5.8) | 2.3 (1.1 to 5.7) | 4.9 (1.8 to 12.5) | 2.1 (1.0 to 6.1) | 4.2 (1.5 to 9.6) | 0.004 | 2.8 (0.9 to 8.0) | 4.5 (1.6 to 11.0) | 0.362 |
Death within PICU | |||||||||
First admission, n (%) | 2,871 (4.3) | 1,397 (4.1) | 140 (9.7) | 663 (4.3) | 86 (9.5) | 0.888 | 154 (4.6) | 20 (8.8) | 0.665 |
Any admission, n (%) | 4,224 (6.3) | 1,944 (5.6) | 382 (26.5) | 948 (6.1) | 223 (24.8) | 0.339 | 220 (6.6) | 54 (23.8) | 0.383 |
Readmission to PICU (first admissions 2008-2016), n (%) | |||||||||
>1 admission, n (%) | 14,341 (25.8) | 7,419 (26.5) | 848 (75.7) | 3,429 (27.5) | 555 (76.3) | 0.733 | 901 (33.3) | 153 (80.1) | 0.181 |
Number of admissions, median (IQR) | 1 (1 to 2) | 1 (1 to 2) | 3 (2 to 5) | 1 (1 to 2) | 3 (2 to 5) | 0.677 | 1 (1 to 2) | 3 (2 to 5) | 0.823 |