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Table 2 Clinical characteristics and therapeutic results between LEV group and Other ASMs group

From: Levetiracetam may be an unsuitable choice for patients with PRRT2-associated self-limited infantile epilepsy

 

LEV group (n = 16)

Other AEDs group (n = 23)

Statistic

P

Gender (male/female)

10/6

11/12

-

0.516#

Onset age [M (P25 ~ P75), m]

5.25 (3.25 ~ 6.00)

4.00 (4.00 ~ 5.00)

Z = 1.174*

0.240

Distribution of variation [n (%)]

    

Microdeletion

5 (31.25%)

2 (8.70%)

χ2 = 3.542#

0.315

Duplication

7 (43.75%)

15 (65.22%)

Missense

1 (6.25%)

2 (8.70%)

Deletion

3 (18.75%)

4 (17.39%)

EEG

    

Normal

3 (18.75%)

4 (17.39%)

χ2  = 0.243#

1.000#

MFD

4 (25.00%)

5 (21.74%)

FD

9 (56.25%)

14 (60.87%)

Epileptic phenotype

    

Focal

3 (18.75%)

5 (21.74%)

χ2  = 0.209#

1.000#

FBTCS

11 (68.75%)

15 (65.22%)

Focal + FBTCS

2 (12.50%)

3 (13.04%)

Therapeutic effect [n (%)]

    

Effective

2 (12.50%)

22 (95.65%)

χ2  = 29.541#

0.000

Ineffective

5 (31.25%)

1 (4.35%)

Aggravated

9 (56.25%)

0

Effective time∆ [M (P25 ~ P75),d]

15.00 (9.50 ~ 45.00)

1.00 (1.00 ~ 1.00)

Z = 4.912*

0.000

  1. Abbreviation: FBTCS, focal to bilateral tonic-clonic seizures; FD, focal discharges; MFD, multiple focal discharges
  2. * Mann-Whitney U test, # Fisher’s exact test. ∆ Effective time: time from ASM treatment to seizure free