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Table 3 Top 10 drugs in terms of ROR in children

From: Liver injury in children: signal analysis of suspected drugs based on the food and drug administration adverse event reporting system

Drug (ATC code-5th level)

Number of reports

PRR

χ²

ROR (95% CI)

Teceleukin (NA)

8

20.9

137.9

179.8 (22.5–1,437.4)

Cefpirome (J01DE02)

3

17.6

33.2

67.4 (7.0–647.8)

Trabectedin (L01CX01)

5

16.8

61.8

56.2 (10.9–289.5)

Ciprofloxacin (J01MA02)

6

15.6

71.3

44.9 (11.2–179.7)

Propoxyphene napsylate (NA)

4

15.6

43

44.9 (8.2–245.3)

Vandetanib (L01XE12)

11

14.3

128.9

35.3 (13.7–91.1)

Calcium levofolinate (V03AF04)

3

14.1

25.6

33.7 (5.6–201.6)

Valsartan and amlodipine (C09DB01)

9

12.4

87.1

25.3 (9.8–65.5)

Aclarubicin (L01DB04)

3

11.7

20.6

22.5 (4.5–111.3)

Sovaprevir (M09AX09)

14

11.7

132.5

22.5 (10.7–47.2)

  1. ATC, anatomic therapeutic chemical; CI, confidence interval; PRR, proportional reporting ratio; ROR, reporting odds ratio