Table 4 Correlation between the severity of NH and vitamin D metabolic pathway genes polymorphisms

NADSYN1/DHCR7 rs12785878

Genotype

GG

15 (19.74%)

33 (35.48%)

7 (38.89%)

1

1

GT

45 (59.21%)

37 (39.79%)

7 (38.89%)

2.47 (1.27, 4.79)

0.008

2.43 (1.22, 4.86)

0.012

TT

16 (21.05%)

23 (24.73%)

4 (22.22%)

1.51 (0.69, 3.28)

0.300

1.37 (0.61, 3.05)

0.445

Allele

G

75 (49.34%)

103 (55.38%)

21 (58.33%)

1

1

T

77 (50.66%)

83 (44.62%)

15 (41.67%)

1.29 (0.87, 1.91)

0.201

1.23 (0.82, 1.85)

0.312

Dominant model

GT + TT

61 (80.26%)

60 (64.52%)

11 (61.11%)

2.09 (1.12, 3.88)

0.020

1.97 (1.04, 3.73)

0.037

GG

15 (19.74%)

33 (35.48%)

7 (38.89%)

1

1

Recessive model

GG + GT

60 (78.95%)

70 (75.27%)

14 (77.78%)

0.87 (0.45, 1.68)

0.678

0.82 (0.41, 1.63)

0.570

TT

16 (21.05%)

23 (24.73%)

4 (22.22%)

1

1

GC rs4588

Genotype

CC

40 (52.63%)

45 (48.39%)

6 (33.33%)

1

1

CA

26 (34.21%)

37 (39.78%)

8 (44.45%)

0.71 (0.39, 1.29)

0.257

0.71 (0.38, 1.33)

0.291

AA

10 (13.16%)

11 (11.83%)

4 (22.22%)

0.71 (0.30, 1.66)

0.426

0.76 (0.31, 1.86)

0.551

Allele

C

106 (69.74%)

127 (68.28%)

20 (55.56%)

1

1

A

46 (30.26%)

59 (31.72%)

16 (44.44%)

0.78 (0.51, 1.18)

0.240

0.81 (0.52, 1.24)

0.330

Dominant model

CA + AA

36 (47.37%)

48 (51.61%)

12 (66.67%)

0.71 (0.41, 1.23)

0.220

0.73 (0.41, 1.29)

0.277

CC

40 (52.63%)

45 (48.39%)

6 (33.33%)

1

1

Recessive model

CC + CA

66 (86.84%)

82 (88.17%)

14 (77.78%)

0.82 (0.36, 1.85)

0.636

0.88 (0.38, 2.06)

0.770

AA

10 (13.16%)

11 (11.83%)

4 (22.22%)

1

1

GC rs7041

Genotype

TT

41 (53.95%)

38 (40.86%)

11 (61.11%)

1

1

TG

26 (34.21%)

32 (34.41%)

5 (27.78%)

0.95 (0.51, 1.76)

0.863

0.85 (0.44, 1.63)

0.619

GG

9 (11.84%)

23 (24.73%)

2 (11.11%)

0.62 (0.29, 1.33)

0.221

0.69 (0.31, 1.52)

0.355

Allele

T

108 (71.05%)

108 (58.06%)

27 (75.00%)

1

1

G

44 (28.95%)

78 (41.94%)

9 (25.00%)

0.77 (0.51, 1.16)

0.205

0.79 (0.52, 1.21)

0.285

Dominant model

TG + GG

35 (46.05%)

55 (59.14%)

7 (38.89%)

0.81 (0.47, 1.41)

0.460

0.78 (0.44, 1.39)

0.406

TT

41 (53.95%)

38 (40.86%)

11 (61.11%)

1

1

Recessive model

TT + TG

67 (88.16%)

70 (75.27%)

16 (88.89%)

0.63 (0.31, 1.31)

0.217

0.74 (0.35, 1.55)

0.421

GG

9 (11.84%)

23 (24.73%)

2 (11.11%)

1

1

CYP2R1 rs12794714

Genotype

CC

35 (46.05%)

35 (37.63%)

6 (33.33%)

1

1

CT

31 (40.79%)

37 (39.79%)

10 (55.56%)

0.72 (0.39, 1.33)

0.298

0.81 (0.43, 1.56)

0.535

TT

10 (13.16%)

21 (22.58%)

2 (11.11%)

0.62 (0.28, 1.37)

0.241

0.54 (0.24, 1.24)

0.149

Allele

C

101 (66.45%)

107 (57.53%)

22 (61.11%)

1

1

T

51 (33.55%)

79 (42.47%)

14 (38.89%)

0.750 (0.50, 1.12)

0.162

0.72 (0.48, 1.10)

0.128

Dominant model

CT + TT

41 (53.95%)

58 (62.37%)

12 (66.67%)

0.69 (0.39, 1.21)

0.198

0.72 (0.39, 1.30)

0.271

CC

35 (46.05%)

35 (37.63%)

6 (33.33%)

1

1

Recessive model

CC + CT

66 (86.84%)

72 (77.42%)

16 (88.89%)

0.73 (0.35, 1.52)

0.402

0.60 (0.28, 1.29)

0.189

TT

10 (13.16%)

21 (22.58%)

2 (11.11%)

1

1

CYP24A1 rs17216707

Genotype

TT

70 (92.11%)

83 (89.25%)

14 (77.78%)

1

1

CT

6 (7.89%)

10 (10.75%)

4 (22.22%)

0.50 (0.20, 1.24)

0.134

0.53 (0.21, 1.35)

0.183

Allele

T

146 (96.05%)

176 (94.62%)

32 (88.89%)

1

1

C

6 (3.95%)

10 (5.38%)

4 (11.11%)

0.52 (0.22, 1.25)

0.144

0.55 (0.22, 1.37)

0.199

CYP27B1 rs10877012

Genotype

GG

19 (25.00%)

27 (29.03%)

4 (22.22%)

1

1

GT

35 (46.05%)

42 (45.16%)

10 (55.56%)

0.99 (0.51, 1.95)

0.990

1.01 (0.50, 2.06)

0.969

TT

22 (28.95%)

24 (25.81%)

4 (22.22%)

1.22 (0.57, 2.60)

0.605

1.18 (0.54, 2.60)

0.677

Allele

G

73 (48.03%)

96 (51.61%)

18 (50.00%)

1

1

T

79 (51.97%)

90 (48.39%)

18 (50.00%)

1.11 (0.75, 1.66)

0.589

1.10 (0.73, 1.64)

0.659

Dominant model

GT + TT

57 (75.00%)

66 (70.97%)

14 (77.78%)

1.07 (0.58, 2.00)

0.823

1.08 (0.56, 2.07)

0.826

GG

19 (25.00%)

27 (29.03%)

4 (22.22%)

1

1

Recessive model

GG + GT

54 (71.05%)

69 (74.19%)

14 (77.78%)

1.22 (0.66, 2.29)

0.526

1.17 (0.61, 2.25)

0.632

TT

22 (28.95%)

24 (25.81%)

4 (22.22%)

1

1