Table 2 Correlation between NH and vitamin D deficiency and correlation between vitamin D deficiency and its metabolic pathway genes polymorphisms
|  | Non-vitamin D deficiency (n = 65) | Vitamin D deficiency (n = 271) | Crude OR (95% CI) | P-Value | Adjusted OR (95% CI) | P-Value |
|---|---|---|---|---|---|---|
Control group | 36 (55.38%) | 113 (41.70%) | 1 | Â | 1 | Â |
NH group | 29 (44.62%) | 158 (58.30%) | 1.74 (1.01, 2.99) | 0.048 | 1.18 (0.65, 2.14) | 0.588 |
NADSYN1/DHCR7 rs12785878 | ||||||
GG | 17(26.15%) | 67 (24.72%) | 1 | Â | 1 | Â |
GT | 30 (46.15%) | 129 (47.60%) | 0.67 (0.39, 1.16) | 0.153 | 0.69 (0.39, 1.24) | 0.218 |
TT | 18 (27.70%) | 75 (27.68%) | 0.45 (0.25, 0.83) | 0.011 | 0.45 (0.23, 0.86) | 0.016 |
GC rs4588 | ||||||
CC | 38 (58.46%) | 120 (44.28%) | 1 | Â | 1 | Â |
CA | 22 (33.85%) | 117 (43.17%) | 0.77 (0.49, 1.22) | 0.261 | 0.79 (0.49, 1.30) | 0.359 |
AA | 5 (7.69%) | 34 (12.55%) | 1.31 (0.64, 2.72) | 0.460 | 1.22 (0.56, 2.65) | 0.620 |
GC rs7041 | ||||||
TT | 24 (36.92%) | 142 (52.40%) | 1 | Â | 1 | Â |
TG | 30 (46.16%) | 90 (33.21%) | 0.93 (0.58, 1.49) | 0.774 | 1.09 (0.65, 1.80) | 0.750 |
GG | 11 (16.92%) | 39 (14.39%) | 1.79 (0.92, 3.50) | 0.086 | 1.55 (0.76, 3.15) | 0.224 |
CYP2R1 rs12794714 | ||||||
CC | 29 (44.61%) | 108 (39.85%) | 1 | Â | 1 | Â |
CT | 28 (43.08%) | 113 (41.70%) | 0.99 (0.62, 1.59) | 0.979 | 0.97 (0.58, 1.61) | 0.902 |
TT | 8 (12.31%) | 50 (18.45%) | 1.06 (0.57, 1.97) | 0.855 | 1.14 (0.59, 2.23) | 0.692 |
CYP24A1 rs17216707 | ||||||
TT | 56 (86.15%) | 247 (91.14%) | 1 | Â | 1 | Â |
CT | 9 (13.85) | 24 (8.86%) | 1.25 (0.60, 2.61) | 0.547 | 1.19 (0.54, 2.61) | 0.665 |
CYP27B1 rs10877012 | ||||||
GG | 19 (29.23%) | 56 (20.66%) | 1 | Â | 1 | Â |
GT | 30 (46.15%) | 130 (47.97%) | 0.60 (0.34, 1.06) | 0.076 | 0.53 (0.29, 0.98) | 0.042 |
TT | 16 (24.62%) | 85 (31.37%) | 0.49 (0.26, 0.90) | 0.023 | 0.60 (0.31, 1.16) | 0.131 |