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Table 2 Comparison according to CMV infection

From: Prevention of human milk-acquired cytomegalovirus infection in very-low-birth-weight infants

Variables

CMV infection

Univariate logistic

regression analysis

Yes

(n = 7)

No

(n = 118)

P-value

Odds ratio

(95% CI)

P-value

Gestational age (weeks)

27.86 ± 3.44

27.73 ± 2.68

0.63 2

0.97 (0.71–1.31)

0.81

Body weight (g)

1012.86 ± 271

1044.59 ± 358

0.82 2

1.00 (1.00–1.00)

0.82

Delivery type (NSVD / CS)

3 / 4

26 / 92

0.35 1

0.38 (0.08–1.79)

0.22

Sex (male / female)

2 / 5

61 / 57

0.27 1

2.68 (0.50-14.34)

0.25

Small for gestational age

1 (14.3)

20 (16.9)

1.00 1

0.79 (0.14–4.56)

0.80

Type of pregnancy

     

Single / twin or triplet

6 / 1

47 / 71

0.04 1

0.11 (0.01–0.95)

0.04

Surfactant use

6 (85.7)

96 (81.4)

1.00 1

1.37 (0.16–12.01)

0.77

Bronchopulmonary dysplasia

4 (57.1)

70 (59.3)

1.00 1

0.91 (0.20–4.27)

0.91

Significant patent ductus arteriosus*

3 (42.9)

51 (43.2)

1.00 1

0.99 (0.21–4.60)

0.98

ROP (≥ stage 2)

2 (28.6)

24 (20.3)

0.63 1

1.57 (0.29–8.58)

0.60

Necrotizing enterocolitis

0 (0.0)

17 (14.4)

0.59 1

N/E

 

Sepsis

2 (28.6)

45 (38.1)

0.71 1

0.65 (0.12–3.49)

0.61

Numbers of transfusion

     

Packed red blood cell

11.43 ± 11.47

7.18 ± 9.50

0.38 1

1.04 (0.97–1.11)

0.27

Platelet concentrate

5.29 ± 9.39

3.64 ± 9.46

0.97 1

1.01 (0.95–1.08)

0.66

Fresh frozen plasma

0.43 ± 0.79

1.53 ± 7.62

0.74 1

0.83 (0.39–1.76)

0.62

Total parental nutrition days

47.57 ± 28.59

40.74 ± 28.83

0.42 3

1.01 (0.98–1.03)

0.54

Days to achieve full enteral feeding

44.14 ± 31.68

41.55 ± 31.40

0.69 3

1.00 (0.98–1.03)

0.83

Average HM intake (mL/day)

80.55 ± 45.74

81.51 ± 58.21

0.70 3

1.00 (0.99–1.01)

0.97

Proportion of HM in total enteral intake

     

< 25%

1 (14.3)

15 (12.7)

0.331

Reference

 

25% – 49%

1 (14.3)

42 (35.6)

 

0.36 (0.02–6.08)

0.48

50% – 75%

4 (57.1)

30 (25.4)

 

2.00 (0.21–19.50)

0.55

> 75%

1 (14.3)

31 (26.3)

 

0.48 (0.03–8.28)

0.62

Study group

     

FT

2 (28.6)

39 (33.1)

0.40 1

Reference

 

FT + LP

4 (57.1)

38 (32.2)

 

2.05 (0.35–11.87)

0.42

FT + HP

1 (14.3)

41 (34.7)

 

0.48 (0.04–5.46)

0.55

  1. Values are either n (%) or mean ± standard deviation
  2. *Defined as conditions needing medical or surgical treatment
  3. 1Fisher’s exact test, 2Independent t-test, 3Mann–Whitney U test, N/E: not estimable
  4. Abbreviations: CMV, cytomegalovirus; CI, confidence interval; NSVD, normal spontaneous vaginal delivery; CS, cesarean section; ROP, retinopathy of prematurity; HM, human milk; FT, freeze-thawing; LP, low-temperature Holder pasteurization; HP, high-temperature short-term pasteurization