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Table 2 Laboratory findings of pediatric cases infected with Alpha, Delta, and Omicron variants

From: Clinical and laboratory features of SARS-CoV-2 variants across multiple rounds of pandemic waves in hospitalized children in an Iranian referral hospital

Variable (normal range)

Variant

P value

Alpha

Delta

Omicron

Total

White blood cell count (4–10 × 109/L)

7.68 ± 4.84

7.54 ± 3.42

8.63 ± 3.55

7.91 ± 3.54

0.409

Red blood cell count (3.5–5.5 × 109/L)

4.09 ± 1.07

15.63 ± 60.03

4.49 ± 0.54

11.25 ± 47.00

0.561

Hemoglobin (10–16 g/dL)

10.86 ± 2.56

12.13 ± 1.37

12.32 ± 1.48

12.12 ± 1.50

0.131

Platelet count (150–450 × 109/L)

241.00 ± 98.05

261.47 ± 94.42

268.90 ± 111.61

262.77 ± 99.67

0.840

Neutrophil count (2–7 × 109/L)

4.76 ± 3.74

4.33 ± 3.47

5.02 ± 2.64

4.59 ± 3.21

0.650

Lymphocyte count (0.8-4.0 × 109/L)

2.04 ± 1.73

2.41 ± 1.80

2.66 ± 2.33

2.47 ± 1.97

0.761

Blood urea nitrogen (5–20 mg/dL)

12.40 ± 12.38

12.99 ± 13.94

12.07 ± 7.66

12.65 ± 11.97

0.946

Creatine phosphokinase (24–172 U/L)

110.25 ± 83.58

173.31 ± 239.60

1329.75 ± 3911.56

416.61 ± 1825.64

0.148

Lactate dehydrogenase (5–746 U/L)

494.00 ± 50.41

558.97 ± 268.56

587.38 ± 428.05

561.43 ± 304.09

0.865

Calcium (8.5–10.2 mg/dL)

8.95 ± 1.32

19.23 ± 64.35

8.93 ± 0.88

15.17 ± 50.10

0.723

Phosphorus (2.8–4.5 mg/dL)

4.30 ± 1.59

4.49 ± 1.41

5.08 ± 1.05

4.68 ± 1.32

0.206

Sodium (135–145 mmol/L)

136.20 ± 4.32

135.00 ± 22.74

137.15 ± 2.73

135.76 ± 17.94

0.882

Potassium (3.7–5.9 mmol/L)

3.78 ± 0.68

4.32 ± 0.61

4.09 ± 0.51

4.21 ± 0.63

0.070

Prothrombin time (9.5–13.5 s)

18.38 ± 5.35

16.70 ± 6.34

16.03 ± 2.66

16.65 ± 5.60

0.759

Partial thromboplastin time (< 65 s (< 2 months), 30–45 s (> 2 months))

43.25 ± 12.18

38.81 ± 10.36

35.27 ± 6.37

38.26 ± 9.75

0.276

International normalized ratio

1.35 ± 0.39

1.25 ± 0.50

1.18 ± 0.21

1.24 ± 0.44

0.758

Erythrocyte sedimentation rate (0–10 mm/h)

17.50 ± 18.45

15.88 ± 15.13

11.25 ± 6.23

14.42 ± 13.07

0.286

Vitamin D (20–40 ng/mL)

25.50 ± 11.15

30.08 ± 8.95

24.50 ± 12.32

28.56 ± 9.80

0.379

CK-MB (5–25 IU/L)

21.00 ± 11.14

35.30 ± 29.14

400.18 ± 1036.94

107.42 ± 469.04

0.085

Troponin (0–0.3 ng/ml)

0.01 ± 0.01

0.10 ± 0.07

0.15 ± 0.05

0.10 ± 0.07

0.044

Fibrinogen (150–350 mg/dL)

242.75 ± 42.94

306.67 ± 99.81

266.58 ± 76.72

294.19 ± 94.24

0.229

 C-reactive protein (< 6 mg/L)

4 (1.65–25.5)

4 (1.9–28.5)

1 (1–2)

2 (1–13)

< 0.0001

Magnesium (1.7–2.2 mg/dL)

2.15 (1.85–2.75)

2.2 (1.85–2.75)

2.1 (1.9–2.4)

2.1 (1.9–2.4)

0.27

Aspartate aminotransferase (10–40 U/L)

40 (24.5–888)

40 (24.5–888)

32 (22–41)

38 (29-47.7)

0.09

Alanine transaminase (10–40 U/L)

17.5 (15.2-209.5)

17.5 (15.2-209.5)

20 (13–22)

18.5 (16–25)

0.65

Ferritin (30–220 ng/mL)

85.5 (56.5–611)

91.5 (43.5–172)

66.5 (42–169)

87 (45.5–170)

0.75

D-dimer (< 500 ng/ml)

268.5 (136–5545)

353 (200–668)

500 (262–863)

357 (201–681)

0.7