Anti-tissue transglutaminase antibodies (TG2A) positivity and the risk of vitamin D deficiency among children - a cross-sectional study in the generation R cohort

Table 2 Associations between TG2A positivity (binary independent variable) and serum 25(OH)D concentrations (continuous dependent variable) at 6 years of age, for the total population and for HLA DQ2 and/or HLA DQ8 positive children (imputed data)

	25 (OH) D concentrations (nmol/L)
TG2A concentrations U/ml	Crude model β (95% CI)	Model 1 aβ (95% CI)	Model 2 aβ (95% CI)
TG2A negative n = 3940	Reference	Reference	Reference
TG2A positive n = 54	-2.20 (-9.72;5.33)	-2.20 (-8.73;4.33)	-1.73 (-8.31;4.85)
	25 (OH) D concentrations (nmol/L)
TG2A concentrations U/ml among HLA DQ2 and/or HLA DQ8 positive children	Crude model β (95% CI)	Model 1 aβ (95% CI)	Model 2 aβ (95% CI)
TG2A negative n = 1070	Reference	Reference	Reference
TG2A positive n = 35	-1.17 (-10.43;8.09)	-2.11 (-10.14;5.91)	-1.19 (-9.05; 6.66)

Values (β’s) are based on linear regression models and reflect between group differences in serum 25 (OH) D concentrations (nmol/L) at 6 years of age relative to the reference group.
*Denotes statistical significance (P < 0.05)
Model 1 was adjusted for season of blood draw (winter/spring and summer/autumn), and ethnicity (Western and non-Western). Model 2 was adjusted for season of blood draw, ethnicity, 25 (OH) D concentrations of the mother during pregnancy (nmol/L), child’s birth weight (grams), gender (male/ female) and breastfeeding exclusiveness (yes/no).
Abbreviations: β, beta; aβ, adjusted beta; CI, confidence interval.

ISSN: 1471-2431