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Table 1 Characteristics of the children and their mothers, for the total population and split by TG2A positivity (imputed data)

From: Anti-tissue transglutaminase antibodies (TG2A) positivity and the risk of vitamin D deficiency among children - a cross-sectional study in the generation R cohort

 

Total population

(n = 3994)

TG2A positivity at 6 years of age

TG2A negative

(TG2A < 7 U/ml)

(n = 3940)

TG2A positive (TG2A ≥ 7 U/ml)

(n = 54)

p - value a

Child characteristics b

    

Birth weight (grams; mean, SD)

3434 (551.6)

3433.2 (551.0)

3493.7 (604.6)

0.42

Female gender (n,%)

1934 (48.4)

1899 (48.2)

35 (64.8)

0.01

Ethnicity (n,%)

    

Non-Western

1364 (34.2)

1352 (34.3)

12 (22.2)

0.08

Western

2630 (65.8)

2588 (65.7)

42 (77.8)

 

Breastfeeding (n,%)

    

Exclusively breastfed in the first 4 months

1302 (32.6)

1282 (32.1)

20 (37.0)

0.21

Partially breastfed in the first 4 months

2354 (58.9)

2320 (58.1)

33 (61.1)

 

Never breastfed

338 (8.5)

337 (8.4)

1 (1.9)

 

Gluten introduction > 6 months (n,%)

2143 (53.7)

2117 (53.1)

26 (48.1)

0.43

Gastroenteritis in the past year (n, %)

1712 (42.9)

1686 (48.3)

26 (48.1)

0.48

BMI child at 6 years of age (kg/m2; median, IQR)

16.2 (15.1–16.9)

16.2 (15.1–16.9)

15.6 (14.7–16.3)

0.01

Playing outside at 6 years of age (hours/ day; median, IQR)

1.6 (0.8–2.1)

1.6 (0.8–2.1)

1.4 (0.7-2.0)

0.78

Maternal characteristics b

    

Maternal educational level (n,%)

    

Low (≤ secondary education)

2127 (53.3)

2104 (52.7)

23 (42.6)

0.21

High (≥ higher education)

1867 (46.7)

1836 (47.3)

31 (57.4)

 

Maternal smoking during pregnancy (n,%)

641 (16.0)

633 (15.9)

8 (14.8)

0.70

Maternal 25(OH)D serum concentrations second trimester pregnancy (nmol/L; median, IQR)

53.1 (27.3–76.0)

53.2 (27.9–75.6)

53.3 (28.0-79.1)

0.72

  1. Values are frequencies (percentages), means (standard deviations (SD)), or medians (interquartile range (IQR)) from the imputed dataset
  2. a p-values are calculated with the Chi-square test for categorical variables, Mann-Whitney U test for continuous non- normally distributed variables and Student’s T test for continuous normal distributed variables and reflect differences between TG2A positive and negative groups. Fisher’s exact test was obtained in case the expected count was less than five. A p-value < 0.05 was considered significant
  3. b Data are pooled results after multiple imputation