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Table 3 Analysis of prognostic risk factors for OS in all patients

From: Clinical characteristics, treatment and prognosis of infants with retinoblastoma: a multicenter, 10-year retrospective analysis

Factors

Univariate analysis

Multivariate Cox regression analyses

N

OS, n (%)

χ2

P

HR (95% CI)

P

Eye affected

373

364 (97.7)

4.19

0.041

0.206 (0.196–0.257)

0.837

 Unilateral eye

162

161 (99.4)

    

 Bilateral eye

211

203 (96.2)

    

Recurrence

29

26 (89.7)

6.14

0.013

1.376 (0.878–2.156)

0.013

Clinical stages of left eye

291

264 (92.7)

5.76

0.016

3.510 (3.409–3.729)

0.001

 Group A-C

72

67 (93.1)

    

 Group D-E

212

194 (91.5)

    

 Extraocular disease stage

5

3 (60.0)

    

 Not staged

1

0 (0.0)

    

 Eyeball atrophy

1

0 (0.0)

    

Presenting signs

373

364 (97.7)

4.18

0.041

2.304 (2.084–2.419)

0.022

 Leukocoria

277

259 (93.5)

    

 Vision loss and blindness

6

6 (100.0)

    

 Proptosis

2

2 (100.0)

    

 Strabismus

26

24 (92.3)

    

 Ocular motility disorder

5

5 (100.0)

    

 Conjunctival hyperemia

7

7 (100.0)

    

 Infections of the eyeball

23

20 (90.0)

    

 Physical examination

27

22 (81.5)

    
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