Adverse drug events and contributing factors among pediatric cancer patients at Jimma University medical center, Southwest Ethiopia

Table 6 Multivariable logistic regression results for factors associated with the occurrence of ADEs pediatrics with cancer at JUMC

Variables	Category	Grade 3—4 ADEs		COR(95% CI)	P value	AOR (95% CI)	P value
Variables	Category	No	Yes	COR(95% CI)	P value	AOR (95% CI)	P value
Sex	Female	14	13	1.0
Sex	Male	14	32	2.462(0.922–6.572)^*	0.072	3.233(0.816–12.806)	0.095
Age(years)	≥ 12	6	11	1.0
	6–11	10	17	3.208(0.660–15.587)	0.148
	3–6	5	13	2.975(0.694–12.756)	0.142
	< 3	7	4	4.550(0.915–22.627)	0.064
Presence of comorbidity	No	26	22	1.0
Presence of comorbidity	Yes	2	23	13.591(2.878–64.190)^*	0.001	12.700(1.978–81.549)^**	0.007
Risk group	Standard risk	7	3	1.0
Risk group	High risk	9	19	1.091(0.182–6.555)	0.924
Cancer type	Non leukemic	18	7	1.0
Cancer type	Leukemic	10	38	9.771(3.198–29.855)^*	0.000	13.332(3.288–54.059)^**	0.000
Number of CT cycle	1—2 cycle	19	14	1.0
Number of CT cycle	≥ 3 cycle	18	22	0.676(0.260–1.762)	0.424
Number of CT Drugs	1 – 3	19	13	1.0		1.0
Number of CT Drugs	≥ 4	9	32	5.197(1.870–14.440)^*	0.002	6.179(1.894–20.165)^**	0.003
Length of hospital stay	1 – 7	12	6	1.0		1.0
Length of hospital stay	≥ 8	16	39	4.875(1.560–15.239)^*	0.006	5.367(1.167–24.684)^**	0.031

Abbreviations: COR Crude odds ratio, AOR Adjusted Odds Ratio, CT Chemotherapy
^* Significant association; p < 0.25
^** Significant association; p < 0.05

ISSN: 1471-2431