Expression pattern of miR-193a, miR122, miR155, miR-15a, and miR146a in peripheral blood mononuclear cells of children with obesity and their relation to some metabolic and inflammatory biomarkers

Table 7 The comparison of miR-155 expression level among children with and without some metabolic status

Groups	N	Median (IQR)	^@P-value	Groups	N	Median (IQR)	^@P-value
Obesity			0.01	^**Muscle Mass Range			0.13
No	45	0.37(0.61)		Low	41	0.4(0.54)
Yes	45	0.17 (0.43)		Normal	24	0.30(0.58)
Metabolic syndrome			0.10	High	25	0.18(0.39)
No	76	0.33(0.52)		**Fat Mass			0.03
Yes	14	0.08(0.32)		Normal	55	0.36(0.60)
^&High TG			0.26	high	35	0.11(0.44)
No	50	0.35(0.53)		^$$REE			0.59
Yes	40	0.18(0.54)		^~Slow	10	0.17(0.42)
^&Low HDL			0.51	^~Normal	59	0.33(0.52)
No	67	0.34(0.52)		^~Fast	21	0.33(0.53)
Yes	23	1.00(0.54)		*High hs-CRP			0.02
^&Large WC			0.29	No	60	0.34(0.54)
No	67	0.36(0.54)		Yes	29	0.10(0.33)
Yes	23	0.17(0.39)		^%Hyper-insulinemia			0.18
^&High SBP			0.55	No	80	0.33(0.52)
No	80	0.34(0.52)		Yes	10	0.09(0.16)
Yes	10	0.19(0.30)		^#Insulin Resistance			0.06
^&High DBP			0.62	No	76	0.35(0.52)
No	39	0.32(0.52)		Yes	14	0.06(0.16)
Yes	51	0.12(0.60)

^@Mann–Whitney u Test or Kruskal–Wallis test
^& Normal Range according to metabolic syndrome definition in children
^**Desired range reported in each person's body analyzer result sheet, was considered for classification of muscle mass (low-normal-high) and fat mass (low-normal-high)
^$$ Classification for REE (slow-normal-fast) according to desirable ranges reported for each child in Indirect Calorimeter result sheet
^*hs-CRP Reference Value according to sex and age. Normal value in serum (mg/liter): Boys: 5–13 year < 1.45 and 14–18 year < 2.13/Girls: 5–13 year < 1.90 and 14–18 year < 3.33
^# HOMA-IR cut-off values for insulin resistance were calculated to be 2.67 (sensitivity 88.2%, specificity 65.5%) in boys and 2.22 (sensitivity 100%, specificity 42.3%) in girls in the prepubertal period, and 5.22 (sensitivity 56%, specificity 93.3%) in boys and 3.82 (sensitivity 77.1%, specificity 71.4%) in girls in the pubertal period

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