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Table 2 Unadjusted and adjusted logistic regression analysis linking sociodemographic and clinical characteristics with behavioral problems in children with TD

From: Sociodemographic and clinical characteristics of children with tic disorders and behavioral problems: A real-world study and development of a prediction model

 

Unadjusted OR (95% CI)

Adjusted OR (95% CI)

Model 1

Model 2

Model 3

Model 4

Personal factors

 Female

0.64(0.35,1.18)

0.71 (0.38,1.34)

0.71(0.37,1.38)

0.77(0.39,1.52)

0.99(0.48,2.01)

 Age (years)

  6–11

1.69(0.90,3.16)

1.72(0.90,3.28)

1.63(0.84,3.15)

1.60(0.80,3.21)

1.54(0.74,3.21)

  12–16

4.67(1.57,13.89)

5.02(1.62,15.57)

4.27(1.32,13.85)

4.64(1.30,16.50)

4.98(1.27,19.53)

 GA (weeks)

  37–42

0.60(0.19,1.85)

0.42(0.12,1.45)

0.41(0.11,1.44)

0.49(0.13,1.93)

0.42(0.10,1.82)

   > 42

1.12(0.20,6.23)

1.50(0.26,8.54)

1.29(0.22,7.67)

1.78(0.30,10.70)

1.86(0.26,13.11)

 BW (g)

  2500–4000

1.32(0.26,6.67)

1.06(0.19,6.02)

1.24(0.21,7.26)

1.08(0.17,6.75)

1.34(0.20,9.12)

   > 4000

1.15(0.17,7.74)

0.88(0.12,6.68)

0.87(0.11,6.91)

0.66(0.07,6.01)

0.78(0.08,7.85)

 Cesarean

0.93(0.57,1.50)

0.99(0.59,1.64)

0.96(0.57,1.62)

1.04(0.59,1.81)

1.08(0.60,1.94)

 Abnormal birth history

1.99(1.22,3.24)

2.05(1.21,3.45)

2.15(1.26,3.67)

1.95(1.10,3.47)

1.90(1.03,3.50)

 With underlying diseases

1.41(0.87,2.27)

1.29(0.78,2.13)

1.27(0.75,2.13)

1.15(0.66,1.99)

1.08(0.61,1.91)

Parental factors

 Maternal age at pregnancy (years)

  30–35

0.64(0.36,1.14)

 

0.62(0.34,1.14)

0.59(0.30,1.18)

0.51(0.25,1.07)

   > 35

1.41(0.49,4.10)

 

1.48(0.47,4.68)

1.46(0.42,5.14)

1.60(0.41,6.17)

 Method of feeding (within 6 months after birth)

  Formula feeding

1.65(0.95,2.87)

 

1.58(0.86,2.9)

1.75(0.91,3.38)

1.49(0.74,2.99)

  Mixed feeding

0.90(0.51,1.60)

 

0.93(0.50,1.72)

1.04(0.54,1.99)

0.84(0.42,1.68)

 Paternal education level

  Secondary

0.62(0.31,1.24)

 

0.56(0.24,1.32)

0.60(0.24,1.47)

0.64(0.24,1.70)

  University

0.50(0.29,0.88)

 

0.43(0.18,1.06)

0.58(0.22,1.49)

0.59(0.21,1.63)

 Maternal education level

  Secondary

0.75(0.36,1.53)

 

1.04(0.43,2.49)

1.04(0.41,2.61)

1.06(0.38,2.95)

  University

0.65(0.38,1.12)

 

1.38(0.57,3.34)

1.09(0.43,2.77)

1.24(0.46,3.35)

Family-environmental factors

 Family structure

  Stem

1.26(0.78,2.04)

  

0.97(0.50,1.92)

0.75(0.36,1.56)

  Others(non-traditional)

2.17(0.80,5.91)

  

0.96(0.29,3.14)

0.74(0.21,2.64)

 Parenting pattern

  Slant scold

3.50(1.72,7.14)

  

2.02(0.84,4.87)

2.04(0.81,5.11)

  Slant interference

1.76(0.91,3.38)

  

1.20(0.58,2.48)

1.21(0.56,2.60)

  Indulgence

3.25(1.69,6.22)

  

2.1(1.01,4.33)

2.17(1.00,4.69)

 Parental involvement in care

  Partially

1.74(1.03,2.92)

  

2.11(1.04,4.29)

2.11(1.00,4.48)

  None

1.22(0.65,2.28)

  

1.18(0.50,2.76)

1.08(0.44,2.64)

 Inharmony family relationship

2.51(1.39,4.55)

  

1.29(0.60,2.74)

1.19(0.53,2.67)

 Family history

  Parent/close relatives with TD

2.24(0.79,6.36)

  

1.24(0.37,4.17)

1.14(0.31,4.18)

  Parent/close relatives with psychiatric disorders

6.83(1.77,26.33)

  

7.09(1.59,31.56)

6.34(1.33,30.30)

Clinical characteristics

 CTD/TS

3.70(2.19,6.26)

   

3.45(1.82,6.53)

 Complex tics

2.10(1.31,3.34)

   

1.21(0.67,2.19)

 Moderate/Severe tic severity

3.07(1.89,5.00)

   

2.13(1.18,3.84)

  1. Model 1 included personal factors only; Model 2 included personal and parental factors; Model 3 included personal, parental and family-environmental factors; Model 4 included personal, parental, family-environmental factors and clinical characteristics. All factors and associated estimates in Model 1 to Model 4 were listed
  2. The first category of each categorical variable was chosen as the reference