Table 3 Factors associated with mortality amongst neonates with moderate to severe encephalopathy who were cooled

Birth weight categories

N/A

 ≥ 2500 g

56 (83.6)

291 (89.0)

1

_

 < 2500 g

11 (16.4)

36 (11.0)

0.63 (0.30–1.31)

0.213

Gestational age categories

 ≥ 38 weeks

46 (69.7)

217 (66.4)

1

_

1

_

 < 38 weeks

20 (30.3)

63 (19.3)

1.82 (1.00–3.31)

0.045

1.47 (0.70–3.11)

0.307

Sex

N/A

 Female

27 (40.3)

122 (37.5)

1

_

 Male

40 (59.7)

203 (62.5)

0.89 (0.52–1.52)

0.672

Apgar score at 5 min

N/A

 ≥ 4

52/66 (78.8)

275/321 (85.7)

1

_

 0–3

14/66 (21.2)

46/321 (14.3)

1.61 (0.82–3.15)

0.16

Time to First Breath

 < 20 min

35/48 (72.9)

220/251 (87.6)

1

_

1

_

 ≥ 20 min

13/48 (27.1)

31/251 (12.4)

2.64 (1.25–5.58)

0.008

1.86 (0.74–4.63)

0.184

Sarnat staging

 Stage 2 (moderate encephalopathy)

48/67 (71.6)

306/327 (93.6)

1

_

1

_

 Stage 3 (severe encephalopathy)

19/67 (28.4)

21/327 (6.42)

5.77 (2.81–11.8)

0.001

2.04 (0.74–5.67

0.17

Thompson score

 ≤ 10

22/65 (33.8)

163/314 (51.9)

1

_

1

 > 10

43/65 (66.2)

151/314 (48.1)

2.11 (1.20–3.71)

0.008

1.52 (0.75–3.08)

0.248

Blood gas, pH

 ≥ 7.00

36/67 (53.7)

214/326 (65.6)

1

_

1

 < 7.00

31/67 (46.3)

112/326 (34.4)

1.65 (0.96–2.81)

0.065

1.01 (0.51–2.00)

0.981

Blood gas, base deficit (mmols/L)

N/A

 ≤ 16

17/66 (25.8)

85/320 (26.6)

1

_

 > 16

49/66 (74.2)

235/320 (73.4)

1.04 (0.57–1.91)

0.893