Oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants

Table 1 Infant characteristics

	All	No BPD	BPD		P-value
	All	No BPD	Low-Grade (Grade 1)	High-Grade (Grade 2/3)
Number of infants	254	92	83	79
Number of OI data points	6,243	1,147	2,312	2,784
Birth gestation (week)	26.7 ± 1.8	27.8 ± 1.3	26.1 ± 1.8	26.0 ± 1.7	< 0.001^*
Birth weight (gram)	915 ± 287	1,108 ± 255	846 ± 254	761 ± 224	< 0.001^*
Female, n (%)	119 (47%)	53 (58%)	39 (47%)	27 (34%)	0.009^*
Dexamethasone for BPD, n (%)	52 (20%)	0 (0%)	15 (18%)	37 (47%)	< 0.001^*
Started before DOL 21	11 (21%)	-	7 (47%)	4 (11%)	0.013^†
Average daily OI change in the first 21 DOLs	-0.06 ± 0.68	-0.33 ± 0.52 (n = 85)	-0.04 ± 0.75 (n = 82)	0.22 ± 0.65 (n = 75)	< 0.001^*

BPD Bronchopulmonary dysplasia, DOL Day of life (24-h interval), OI Oxygenation index
^*Three-group comparison among No BPD, Low-Grade BPD, and High-Grade BPD
^†Chi-squared test comparing infants who received dexamethasone starting before vs. after DOL 21 between Low- and High-Grade BPD subgroups

ISSN: 1471-2431