Table 1 Histo-anatomical thicknesses comparing aganglionic versus ganglionic bowel wall in 21 children with Hirschsprung’s disease
Histo-anatomical layers | Thickness aganglionosis (millimeters) | Thickness ganglionosis (millimeters) | p-value* | Difference between aganglionic versus ganglionic bowel (%) | Thinner in aganglionosis versus ganglionosis (n) |
|---|---|---|---|---|---|
Full bowel wall | 2.20 (1.26–3.98) | 2.04 (1.66–3.10) | 0.802 | 5 (-42–59) | 10 |
Serosa and subserosa | 0.14 (0.02–0.48) | 0.19 (0.04–0.46) | 0.849 | -16 (-79–325) | 12 |
Muscularis externa | 0.45 (0.15–1.60) | 0.31 (0.21–0.49) | 0.012 | 75 (-48–261) | 9 |
Muscularis interna | 0.45 (0.29–1.02) | 0.62 (0.43–0.97) | < 0.001 | -33 (-54–4) | 19 |
Ratio muscularis interna/externa | 1.00 (0.42–2.34) | 2.07 (1.60–3.40) | < 0.001 | -50 (-88–4) | 20 (lower) |
Myenteric layer | 0.03 (0.006–0.15) | 0.03 (0.007–0.04) | 0.050 | 50 (-77–430) | 8 |
Submucosa | 0.30 (0.17 -1.27) | 0.34 (0.18–0.85) | 0.500 | 0 (-66–182) | 10 |
Submucosa maximum thicknessa | 1.33 (0.46–2.11) | 1.10 (0.76–1.40) | 0.571 | 21 (-53–149) | 7 |
Mucosa | 0.52 (0.31–1.03) | 0.52 (0.37–0.84) | 0.667 | -5 (-54–100) | 11 |