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Table 2 Levels of Evidence Definitions used for Descriptive Synthesis

From: Spinal manipulation and mobilisation in the treatment of infants, children, and adolescents: a systematic scoping review

Level of Evidence

Study Types

Reviews (JBI, 2013)

 Level 1

Level 1.a – Systematic review of Randomised Controlled Trials (RCTs)

Level 1.b – Systematic review of RCTs and other study designs

 Level 2

Level 2.a – Systematic review of quasi-experimental studies

Level 2.b – Systematic review of quasi-experimental and other lower study designs

 Level 3

Level 3.a – Systematic review of comparable cohort studies

Level 3.b – Systematic review of comparable cohort and other lower study designs

 Level 4

Level 4.a – Systematic review of descriptive studies

Studies (NHMRC, 2009)

 II

A randomised controlled trial

 III-1

A pseudorandomised controlled trial (i.e., alternate allocation or some

other method)

 III-2

A comparative study with concurrent controls:

â–ª Non-randomised, experimental trial

â–ª Cohort study

▪ Case–control study

â–ª Interrupted time series with a control group

 III-3

A comparative study without concurrent controls:

â–ª Historical control study

â–ª Two or more single arm study

â–ª Interrupted time series without a parallel control group

 IV

Case series with either post-test or pre-test/post-test outcomes

  1. RCT Randomised Controlled Trials, NHMRC National Health and Medical Research Council, JBI Johanna Briggs Institute
  2. Source: [39, 40]