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Table 2 Results

From: Regular lung recruitment maneuvers during high-frequency oscillatory ventilation in extremely preterm infants: a randomized controlled trial

Results

Total (n = 30)

Intervention (n = 15)

Control (n = 15)

P*

Primary outcome

  Cumulative OSI, mean (SD)

5.13 (1.90)

4.95 (1.72)

5.30 (2.08)

0.61

Secondary outcome

  Average number of recruitments in 12 h, mean (SD)

1.22 (0.40)

1.33 (0.22)

1.11 (0.51)

0.13

  Average number of recruitments, median (min, max), n

11 (1,21)

13 (3, 21)

8 (1, 21)

0.25

  Duration of CMV in study period, median (min, max), h

7.0 (0, 108)

7.3 (0, 55)

6.8 (0, 108)

0.87

  Duration of HFOV in study period, median (min, max), h

121 (30, 173)

127 (30, 173)

104 (34, 161)

0.56

  Total duration of CMV, median (min, max), h

82 (0, 850)

160 (0, 551)

73 (0, 850)

0.27

  Total duration of HFOV, median (min, max), h

129 (31, 445)

131 (31, 445)

107 (34, 254)

0.43

  Averagea S/F ratio, mean (SD)

256 (68)

260 (68)

251 (69)

0.71

  Averagea SpO2, mean (SD) [%]

91.4 (0.8)

91.3 (0.9)

91.5 (0.7)

0.51

  Averagea FiO2, mean (SD) [%]

0.43 (0.14)

0.42 (0.13)

0.43 (0.16)

0.78

  Averagea MAP, mean (SD) [mbar]

10.8 (1.2)

10.5 (1.4)

11.1 (1.0)

0.18

  Maximum MAP in LRM, median (min, max), [mbar]

19 (11, 25)

19 (11, 25)

18 (13, 24)

0.35

  Survival, n (%)

21 (70)

10 (67)

11 (73)

1.0

  BPD (I-III)b, n (%)

18 (60)

10 (67)

8 (53)

0.71

  BPD (I-III)b in survivors, n (%)

21 (76)

9 (90)

7 (64)

0.31

  BPD (II-III)b in survivors, n (%)

5 (24)

4 (40)

1 (9)

0.14

  Pneumothorax, n (%)

5 (17)

3 (20)

2 (13)

1.0

  Severe intraventricular hemorrhage, n (%)

7 (23)

5 (33)

2 (13)

0.39

  Pulmonary interstitial emphysema, n (%)

4 (13)

2 (13)

2 (13)

1.0

  1. BPD Bronchopulmonary dysplasia, CMV conventional mechanical ventilation, h hours, HFOV high frequency oscillation ventilation, LRM lung recruitment maneuver, MAP mean airway pressure
  2. amean over HFOV duration in study period
  3. bBPD as defined in [19]. RM, recruitment maneuver during HFOV duration in study period
  4. *The unpaired t-test for continuous variables, the Fisher’s exact test for categorical data, and the Mann-Whitney U test for nonparametric data