Table 6 Performance of the automated UV enzymatic method and FST in detecting G6PD deficiency and G6PD intermediate newborns
G6PD status | G6PD activity cut-off value (U/g Hb) | Sensitivity (%) (95%CI) | Specificity (%) (95%CI) | PPV (%) (95% CI) | NPV (%) (95% CI) | Positive Likelihood Ratio (95% CI) | Negative Likelihood Ratio (95% CI) | Accuracy (%) (95% CI) |
|---|---|---|---|---|---|---|---|---|
FST | ||||||||
Deficiency | - | 87.1 (76.2–94.3) | 100.0 (99.6–100.0) | 100.0 | 99.2 (98.4–99.6) | - | 0.1 (0.1–0.3) | 99.2 (98.5–99.7) |
Automated UV enzymatic method | ||||||||
Deficiency |  < 7.8 | 98.4 (91.3–100.0) | 99.5 (98.8–99.8) | 92.4 (83.6–96.7) | 99.9 (99.3–100.0) | 187.5 (78.2–449.8) | 0.02 (0.0–0.1) | 99.4 (98.7–99.8) |
Intermediate | 7.8–20.8 | 69.0 (59.7–77.2) | 91.3 (89.3–93.1) | 50.6 (44.5–56.7) | 95.8 (94.6–96.8) | 8.0 (6.2–10.2) | 0.3 (0.3–0.5) | 88.8 (86.7–90.7) |