Table 1 Changes in serum levels of parameters of cholestatic liver damage, iron homeostasis and erythropoiesis
From: Neonatal hemochromatosis with εγδβ-thalassemia: a case report and analysis of serum iron regulators
Days after birth | 9 | 28 | 67 | 86 | 118 | 163 | 170 | 177 | 184 | 191 | 202 |
Hgb (g/dL) (NR: 13.6–18.3) | 6.8 | 6.7 | 6.3 | 7.9 | 6.3 | 8.9 | 7.3 | 7.7 | 8.7 | 6.0 | 7.0 |
Reticulocyte count (%) (NR: 0.2–2.0) | ND | ND | ND | 9.6 | 10.4 | 4.3 | ND | ND | 3.6 | ND | ND |
T-Bil (mg/dL) (NR: 0.3–1.2) | 18.7 | 15.1 | 12.7 | 14.1 | 38.3 | 45.9 | 44.5 | 45.5 | 46.1 | 45.5 | 45.6 |
D-Bil (mg/dL) (NR: < 0.4) | 1.2 | 2.2 | 7.6 | 9.7 | 26.2 | 33.6 | 32.3 | 34.1 | 34.6 | 34.4 | 32.7 |
AST (IU/L) (NR: 10–40) | 13 | 25 | 198 | 365 | 446 | 716 | 730 | 777 | 756 | 956 | 1381 |
ALT (IU/L) (NR: 5–45) | 10 | 24 | 190 | 302 | 275 | 338 | 322 | 298 | 262 | 294 | 320 |
Iron (μg/dL) (NR: 60–210) | 134 | 147 | 139 | 158 | 415 | 479 | 569 | 581 | 557 | 476 | 414 |
Ferritin (ng/mL) (NR: 21–282) | 596 | 795 | 2948 | 6412 | 1829 | 4864 | 3160 | 2422 | 2935 | 1784 | 1430 |
TIBC (μg/dL) (NR: 250–410) | 199 | 178 | 152 | 140 | 602 | 652 | 721 | 711 | 680 | 642 | 554 |
Iron saturation (%) (NR: 20–40) | 67 | 83 | 91 | 92 | 69 | 73 | 79 | 82 | 82 | 74 | 75 |
Hepcidin-25 (ng/mL) (NR: 0.8–14.8) | ND | ND | ND | ND | ND | 5.1 | 1.2 | 0.5 | 0.8 | 0.1 | 0.3 |
GDF-15 (pg/mL) (NR: 337–1060) | ND | ND | ND | ND | ND | 1123 | 1110 | 1358 | 1592 | 1978 | 2168 |