Table 3 Mean pharmacokinetic parameters after single IV infusions of apitegromab
From: Advances and limitations for the treatment of spinal muscular atrophy
Dose (mg/kg) | Cmax (μg/mL) | Tmax (hr) | AUC(0-last) (hr*μg/mL) | AUC(0-inf) (hr*μg/mL) | CL (mL/hr) | Vz (L) | t1/2 (hr) |
|---|---|---|---|---|---|---|---|
1 | 25 | 6.0 | 11,647 | 12,748 | 6.05 | 6.8 | 786 |
3 | 83 | 4.7 | 33,097 | 35,037 | 7.69 | 6.9 | 624 |
10 | 278 | 3.4 | 105,973 | 126,053 | 7.29 | 5.4 | 543 |
20 | 555 | 4.7 | 216,171 | 227,308 | 7.10 | 5.7 | 588 |
30 | 744 | 5.3 | 347,298 | 367,866 | 6.60 | 5.9 | 623 |