Table 5 Change in Symptoms according to the Parent Global Impressions of Autism Score, for the present study, sorted in order from most to least improved, followed by the Overall rating and Average rating. Results for a previous study (treatment and placebo groups), are shown for comparison. The rating is done on a 7-point scale, from -3 (much worse) to 0 (no change) to + 3 (much better). A t-test comparing the present study vs. the treatment group and vs the placebo group of the Adams 2011 study are shown. The raw effect size and net effect size (Cohen’s d) are shown

Receptive Language/Comprehension

1.06 (1.0)

0.91

(1.1)

0.51

(0.92)

n.s

p < 0.001

1.04

0.57

Cognition/Thinking

1.05 (1.0)

0.74

(1.0)

0.43

(0.84)

n.s

p < 0.001

1.04

0.64

Attention/Focus

1.04 (1.0)

1.04

Expressive Language/Speech

0.97 (1.0)

1.09

(1.1)

0.71

(0.92)

n.s

p = 0.10

0.95

0.26

Play/Leisure Skills

0.94

0.81

(0.88)

0.51

(0.87)

n.s

p = 0.005

0.95

0.45

Sociability

0.86 (0.94)

0.77

(0.95)

0.63

(0.92)

n.s

n.s

0.91

0.25

Eye Contact

0.76 (0.91)

0.66

(0.98)

0.40

(0.85)

n.s

p = 0.01

0.84

0.40

Irritability/Mood

0.74 (1.2)

0.63

Tantrums/Meltdowns

0.73 (1.2)

0.4

(1.1)

-0.10

(0.80)

p = 0.07

p < 0.001

0.63

0.77

Stools/GI Problems

0.65 (1.0)

0.68

(1.1)

0.35

(1.1)

n.s

p = 0.10

0.62

0.28

Sensory Sensitivity

0.59 (0.95)

0.62

Anxiety

0.57 (1.1)

0.52

Sleep

0.52 (0.96)

0.3

(0.87)

0.13

(0.99)

n.s

p = 0.02

0.54

0.40

Self-limited Diet (will only eat a few foods)

0.48 (0.88)

0.55

Self-Abusive

0.47 (1.0)

0.46

Aggression

0.45 (1.1)

0.41

Stimming/Perseveration

0.39 (1.1)

0.34

Hyperactivity

0.31 (1.1)

0.31

(0.67)

-0.06

(0.55)

n.s

p = 0.003

0.28

Seizures

0.19 (0.62)

0.32

OVERALL Autism/Related Symptoms

1.11 (0.98)

1.02

(1.0)

0.56

(0.86)

n.s

p < 0.001

1.13

0.57

Average of All Scores

0.75 (0.77)

0.97

Average of scores used in 2011 study

0.82 (0.76)

0.70

(0.65)

0.37

(0.54)

n.s

p < 0.001

1.07

0.66