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Table 2 Comparing variables with and without adverse events during exchange transfusion

From: Understanding the risk factors for adverse events during exchange transfusion in neonatal hyperbilirubinemia using explainable artificial intelligence

Adverse event

Variables

No

Yes

P value

Hyperglycemia

162 (86.2%)

ABO incompatibility

15(57.7%)

50(30.9%)

0.014

ET time

104.88 ± 20.81

95.47 ± 18.22

0.017

ET artery axillary

5(19.2%)

5(3.1%)

0.003

Serum potassium

3.87 ± 0.39

3.65 ± 0.53

0.046

Cerebral hemorrhage

1(3.8%)

42(25.9%)

0.025

Top-up transfusion after et

95 (50.5%)

Admission age

7.00 ± 4.04

5.85 ± 3.83

0.046

Etiology unidentified

57(61.3%)

39(41.1%)

0.009

IBIL at admission

431.34 ± 99.24

394.97 ± 113.56

0.021

TBILbga at admissiona

528.25 ± 111.54

465.65 ± 122.34

 < 0.001

TBILbga before ET

407.01 ± 107.13

370.78 ± 105.68

0.021

Hemoglobin

142.83 ± 33.67

121.18 ± 29.40

 < 0.001

Hypocalcemia

80 (42.6%)

Admission age

7.51 ± 3.64

4.94 ± 3.93

 < 0.001

Breast feeding

76(70.4%)

37(46.2%)

0.001

Formula feeding

9(8.3%)

21(26.2%)

0.002

No feeding

0(0.0%)

7(8.8%)

0.006

RH incompatibility

3(2.8%)

18(22.5%)

 < 0.001

G6PD deficiency

25(23.1%)

5(6.2%)

0.003

Etiology unidentified

64(59.3%)

32(40.0%)

0.014

ET time

99.31 ± 19.56

93.35 ± 17.32

0.032

ET speed

5.09 ± 0.93

5.44 ± 1.02

0.014

ET artery femoral

21(19.4%)

29(36.2)

0.016

TBILbga at admission

528.69 ± 95.60

453.31 ± 137.64

 < 0.001

TBILbga before ET

409.50 ± 103.33

360.62 ± 107.63

0.002

Serum bicarbonate

21.83 ± 2.60

20.64 ± 2.71

0.003

White cell count

12.97 ± 4.77

17.01 ± 10.59

0.001

Hyponatremia

80 (42.6%)

ABO incompatibility

45(41.7%)

20(25.0%)

0.026

ET vein femoral

21(19.4%)

5(6.2%)

0.017

Bilirubin exchange rate

0.46 ± 0.11

0.51 ± 0.08

0.004

Thrombocytopenia

72 (38.3%)

Admission age

6.93 ± 4.14

5.58 ± 3.55

0.023

TBIL at admission

453.56 ± 119.07

403.52 ± 102.60

0.004

TBILbga Before ET

404.76 ± 109.88

362.83 ± 99.35

0.009

Hemoglobin

137.72 ± 32.73

122.49 ± 32.29

0.002

Metabolic acidosis

48 (25.5%)

Gravidity

G2(34.8%);G3(15.6%)

G2(13.3%);G3(31.1%)

0.021

Not feeding

2 (1.4%)

5 (10.4%)

0.017

ABO incompatibility

40(28.6%)

25(52.1%)

0.005

Serum calcium

1.17 ± 0.12

1.13 ± 0.11

0.025

White cell count

13.98 ± 6.92

16.75 ± 10.43

0.039

Hypokalemia

48 (25.5%)

Sex (female)

50(35.7%)

26(54.2%)

0.038

Admission age

7.00 ± 3.98

4.73 ± 3.42

0.001

Breast feeding

91(65.0%)

22(45.8%)

0.030

G6PD deficiency

28(20.0%)

2(4.2%)

0.018

ET vein popliteal

20(14.5%)

0(0.0%)

0.010

TBILbga before ET

398.06 ± 105.39

361.42 ± 110.65

0.042

Serum calcium

1.18 ± 0.11

1.11 ± 0.14

0.001

  1. avariable with subscript bga indicates that the variable was measured by a blood gas analyzer to distinguish it from the biochemistry values