Table 4 Results of multivariable linear regression models testing the association between birthweight (adjusted for sex and gestational age), maternal clinical characteristics and parental heights, with and without the fetal genetic score (n = 549 parent-offspring trios)
Variable | Change in birthweight (g) per 1 SD change in independent variable | 95% Confidence Interval | t value | p-value |
|---|---|---|---|---|
Model 4: maternal clinical characteristics and parental heights (n = 549 parent-offspring trios). R2 = 0.258; Adj-R2 = 0.248 | ||||
Intercept | 3697 | 3650, 3744 | 152.7 | <2e-16 |
Maternal age | −49 | − 84, −15 | −2.8 | 0.005 |
Maternal weight | 101 | 64, 139 | 5.3 | 1e-07 |
Mother’s smoking status | − 251 | − 348, − 155 | −5.1 | 4e-07 |
Parity | −210 | − 278, − 142 | −6.1 | 2e-09 |
Mother’s fasting glucose at 28 weeks’ gestation | 104 | 68, 140 | 5.7 | 2e-08 |
Maternal height | 52 | 16, 87 | 2.9 | 0.004 |
Paternal height | 69 | 35, 102 | 4.0 | 7e-05 |
Model 5: maternal clinical characteristics (n = 549 parent-offspring trios), parental heights, and fetal genetic score. R2 = 0.277; Adj-R2 = 0.264 | ||||
Intercept | 3799 | 3667, 3931 | 56.5 | <2e-16 |
Maternal age | −50 | −84, −16 | −2.9 | 0.004 |
Maternal weight | 97 | 60, 134 | 5.2 | 4e-07 |
Mother’s smoking status | − 241 | − 336, − 146 | −5.0 | 9e-07 |
Parity | − 216 | − 284, − 149 | −6.3 | 6e-10 |
Mother’s fasting glucose at 28 weeks’ gestation | 106 | 71, 142 | 5.9 | 7e-09 |
Maternal height | 49 | 14, 84 | 2.7 | 0.007 |
Paternal height | 66 | 33, 99 | 3.9 | 0.0001 |
Fetal genetic score for offspring birthweight (adjusted for maternal effects) | 56 | 23, 88 | 3.4 | 0.0007 |