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Table 2 Annual Bleeding Rate and laboratory results before and after transition to Emicizumab

From: Emicizumab in children: bleeding episodes and outcome before and after transition to Emicizumab

Patient number ABR total Pre-Emicizumab ABR total Post-Emicizumab ABR spont.a Pre-Emicizumab ABR spont.a Post-Emicizumab ABR traumatic Pre-Emicizumab ABR
traumatic Post-Emicizumab
ABR joint Pre-Emicizumab ABR joint Post-Emicizumab Emicizumab (μg/ml) level
after 3 doses (3 mg/kg)
Emicizumab level
at first follow-up (1.5 mg/kg)
1 4 0 0 0 4 0 0 0 56.8 56.8
2 0 0 0 0 0 0 0 0 34.4 68.4
3 1 0 0 0 1 0 0.5 0 51.9 51.9
4 0 0 0 0 0 0 0 0 49.9 75
5 0.16 0 0 0 0 0 0 0 37.4 66.3
6 1.5 0 0.25 0 1.13 0 0.5 0 43.2 51.6
7 0.08 0 0.1 0 0 0 0 0 41.4 49.9
8 0.53 0 0.16 0 0.24 0 0.16 0 48.4 51.8
9 0.4 0.5 0.18 0 0.24 0.06 0.18 0 43.7 63.5
10 0 0 0 0 0 0 0 0 35.1 56.1
11 0.33 0 0.33 0 0.33 0 0.33 0 23.9 30.4
12 0.11 0 0.18 0 0 0 0 0 39.6 38.1
13 1.55 0 1 0 0.27 0 0.63 0 52.1 41.7
Median (Min–Max) 0.25
(0–4)
0
(0–0.5)*
0.05
(0–1)
0
(0–0)*
0.23
(0–4)
0
(0–0.06)*
0.06
(0–0.63)
0
(0–0)*
43.2
(23.9–56.8)
51.9
(30.4–75)
  1. aspont Spontaneous
  2. *p < 0.05