Table 2 Evaluation of primary outcome variables during the treatment in both the groups
From: Oral lactase for infantile colic: a randomized double-blind placebo-controlled trial
Outcome | Lactase Mean (SD) | Placebo Mean (SD) | Mean Difference (95% CI) | P value |
|---|---|---|---|---|
Week 1 | ||||
Crying or fussing duration (min/d) | 240.7 (109.4) | 301.7 (112.0) | -61.1 (-95.3, -26.6) | 0.001 |
Crying duration (min/d) | 137 (59.3) | 172.2 (66.4) | -35.1 (-54.7, -15.6) | 0.001 |
Fussing duration (min/d) | 103.7 (58.5) | 130.9 (56.3) | -27.1(-44.9, -9.3) | 0.003 |
Week 2 | ||||
Crying and fussing duration (min/d) | 174.8 (120.3) | 241.7 (126.4) | -66.8 (-105.2, -28.4) | 0.001 |
Crying duration (min/d) | 98.6 (67.1) | 138.8 (76.5) | -40.2 (-62.6, -17.7) | 0.001 |
Fussing duration (min/d) | 79.2 (59.7) | 105.8 (59.5) | -26.6 (-45.1, -8) | 0.005 |
Week 3 | ||||
Crying and Fussing duration (min/d) | 110.3 (114.7) | 199.4 (144.8) | -89.1 (-130.4, -47.7) | 0.001 |
Crying duration (min/d) | 61.3 (61.8) | 113.5 (82.9) | -52.2 (-75.4, -29) | 0.001 |
Fussing duration (min/d) | 49.0 (57.5) | 86.0 (67.1) | -36.9 (-56.7, -17.2) | 0.001 |
Week 4 | ||||
Crying and fussing duration (min/d) | 89.9 (115.2) | 178.5 (153.2) | -88.6 (-131.8, -45.4) | 0.001 |
Crying duration (min/d) | 49.9 (63.54) | 100 (86.0) | -50 (-74.1, -25.9) | 0.001 |
Fussing duration (min/d) | 39.9 (55.2) | 78.5 (71.1) | -38.5 (-58.9, -18.2) | 0.001 |
Average (over 4 weeks) | ||||
Crying or fussing duration (min/d) | 155.1 (101.5) | 234.1 (127.1) | -79.1 (-114.7, -43.4) | < 0.001 |
Crying duration (min/d) | 86.55 (54.8) | 132.4 (72.8) | -45.9 (-66.0, -25.9) | < 0.001 |
Fussing duration (min/d) | 68.6 (51.3) | 101.8 (59.2) | -33.2 (-50.4, -16.0) | < 0.001 |
Colic days | 12.1 (7.8) | 17.6 (8.4) | -5.5 (-8.0, -2.3) | < 0.001 |