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Table 4 Cause of death: Diagnostic accuracy and concordance compared with conventional autopsy

From: Post-mortem magnetic resonance imaging with computed tomography-guided biopsy for foetuses and infants: a prospective, multicentre, cross-sectional study

 

TP n

FP n

TN n

FN n

Concordance % (95% CI)

Sensitivity % (95% CI)

Specificity % (95% CI)

PPV % (95% CI)

NPV % (95% CI)

All cases (n = 101)

 Virtopsy

86

7

5

3

90.1 (82.7 to 94.5)

96.6 (90.6 to 98.8)

41.7 (19.3 to 68.0)

92.5 (85.3 to 96.3)

62.5 (30.6 to 86.3)

 Clinical evaluation

59

12

6

24

64.4 (54.6 to 73.0)

71.1 (60.6 to 79.7)

33.3 (16.3 to 56.3)

83.1 (72.7 to 90.1)

20.0 (9.5 to 37.3)

Foetuses ≤ 24 weeks (n = 58)

 Virtopsy

50

2

4

2

93.1 (83.6 to 97.3)

96.2 (87.0 to 98.9)

66.7 (30.0 to 90.3)

96.2 (87.0 to 98.9)

66.7 (30.0 to 90.3)

 Clinical evaluation

36

7

4

11

69.0 (56.2 to 79.4)

76.6 (62.8 to 86.4)

36.4 (15.2 to 64.6)

83.7 (70.0 to 91.9)

26.7 (10.9 to 52.0)

Foetuses > 24 weeks (n = 26)

 Virtopsy

23

1

1

1

92.3 (75.9 to 97.9)

95.8 (79.8 to 99.3)

50.0 (9.5 to 90.5)

95.8 (79.8 to 99.3)

50.0 (9.5 to 90.5)

 Clinical evaluation

12

3

1

10

50.0 (32.1 to 67.9)

54.5 (34.7 to 73.1)

25.0 (4.6 to 69.9)

80.0 (54.8 to 93.0)

9.1 (1.6 to 37.7)

Infants (n = 17)

  Virtopsy

13

4

0

0

76.5 (52.7 to 90.4)

100.0 (77.2 to 100.0)

0.0 (0.0 to 49.0)

76.5 (52.7 to 90.4)

NaN

  Clinical evaluation

11

2

1

3

70.6 (46.9 to 86.7)

78.6 (52.4 to 92.4)

33.3 (6.1 to 79.2)

84.6 (57.8 to 95.7)

25.0 (4.6 to 69.9)

Cases with unclear cause of death after clinical evaluation (n = 30)

 Virtopsy

18

4

5

3

76.7 (59.1 to 88.2)

85.7 (65.4 to 95.0)

55.6 (26.7 to 81.1)

81.8 (61.5 to 92.7)

62.5 (30.6 to 86.3)

Cases with infective deaths (n = 20)

 Virtopsy

17

3

0

0

85.0 (64.0 to 94.8)

100.0 (81.6 to 100.0)

0.0 (0.0 to 53.1)

85.0 (64.0 to 94.8)

NaN

 Clinical evaluation

7

7

6

0

35.0 (18.1 to 56.7)

53.8 (29.1 to 76.8)

0.0 (0.0 to 35.4)

50.0 (26.8 to 73.2)

0.0 (0.0 to 39.0)

  1. TP True positive, FP False positive, TN True negative, FN False negative, PPV Positive predictive value (= TP/TP + FP), NPV Negative predictive value (= TN/TN + FN), NaN Not a number