Table 3 The relation of the studied polymorphisms and alleles of the RANK/RANKL/OPG axis with the performance IQ of TDT children
Gene | TDT performance IQ | ||||
|---|---|---|---|---|---|
mean ± SD | p | unstandardized coefficient β (95% CI) | p | ||
OPG rs2073618 (G > C) | |||||
 Polymorphisms | GG | 75 ± 9 | 0.65 | 12 (−2.2–6.25) | 0.35 |
GC | 77 ± 9 | ||||
CC | 79 ± 10.4 | ||||
 Alleles | C | 78 ± 9.6 | 0.43 | −1.4 -(−4.95–2) | 0.4 |
G | 76.8 ± 8.7 | ||||
RANK rs1805034 (C > T) | |||||
 Polymorphisms | CC | 77.5 ± 3.5 | 0.3 | −1.2- (−4.3–1.9) | 0.43 |
CT | 80.4 ± 10. | ||||
TT | 76 ± 10 | ||||
 Alleles | C | 78.7 ± 7 | 0.4 | −1.6-(−5.15–1.9) | 0.4 |
T | 77 ± 10 | ||||
RANK rs1245811 (A > G) | |||||
 Polymorphisms | AA | 80 ± 15 | 0. 6 | 0.3 (−3.9–4.4) | 0.9 |
AG | 75 ± 10 | ||||
GG | 78 ± 9 | ||||
 Alleles | A | 77 ± 12 | 0.9 | 0.4 (−4.35–5.1) | 0.9 |
G | 77.7 ± 8.7 | ||||
RANK rs75404003 (C > DEL) | |||||
 Polymorphisms | CC | 79 ± 10 | 0.35 | −2.7- (−6.4–1) | 0.15 |
C DEL | 76.3 ± 8 | ||||
DEL DEL | 74 ± 5 | ||||
 Alleles | C | 78.4 ± 9.8 | 0.13 | −2.9-(−6.75–0.9) | 0.13 |
Del | 75.5 ± 7 | ||||
RANKL rs9494782 (C > T) | |||||
 Polymorphisms | CC | 83 ± 12 | 0.12 | 0.45 (−3.4–4.2) | 0.84 |
CT | 74.3 ± 10 | ||||
TT | 79 ± 8 | ||||
 Alleles | C | 77 ± 11 | 0.8 | 0.45 (−3.5–4.4) | 0.8 |
T | 77.8 ± 8.7 | ||||
RANKL rs2277438 (G > A) | |||||
 Polymorphisms | GG | 70 ± 8 | 0.12 | 3.2 (−0.3–6.7) | 0.14 |
GA | 78 ± 10 | ||||
AA | 79 ± 9 | ||||
 Alleles | A | 78.6 ± 9 | 0.02* | −3.9- (−7.8--0.06-) | 0.02* |
G | 74.7 ± 9.5 | ||||