Table 2 The relation of the studied polymorphisms and alleles of the RANK/RANKL/OPG axis with the verbal IQ of TDT children
Gene | TDT verbal IQ | ||||
|---|---|---|---|---|---|
mean ± SD | p | unstandardized coefficient β (95% CI) | p | ||
OPG rs2073618 (G > C) | |||||
 Polymorphisms | GG | 80.5 ± 12 | 0.7 | −0 .95-(−7.3–5.4) | 0.8 |
GC | 85 ± 14 | ||||
CC | 82 ± 14 | ||||
 Alleles | C | 83.4 ± 14 | 0.8 | 0.7(−4.55–5.9) | 0.8 |
G | 84 ± 13.5 | ||||
RANK rs1805034 (C > T) | |||||
 Polymorphisms | CC | 83 ± 7 | 0.01* | −3.7- (−8.3–0.8) | 0.1 |
CT | 92 ± 16 | ||||
TT | 79 ± 13 | ||||
 Alleles | C | 87 ± 12 | 0.1 | −4.98-(−10.2–0.2) | 0.1 |
T | 82 ± 14.4 | ||||
RANK rs1245811 (A > G) | |||||
 Polymorphisms | AA | 86.5 ± 17 | 0.8 | 0.08 (− 6.1–6.3) | 1 |
AG | 81 ± 12 | ||||
GG | 84 ± 14.3 | ||||
 Alleles | A | 83.5 ± 13.4 | 1 | 0.13 (−6.9–7.2) | 1 |
G | 83.6 ± 14 | ||||
RANK rs75404003 (C > DEL) | |||||
 Polymorphisms | CC | 83.5 ± 12 | 0.3 | −1.7 (−7.3–4) | 0.55 |
C DEL | 85 ± 17 | ||||
DEL DEL | 75 ± 11 | ||||
 Alleles | C | 84 ± 13 | 0.53 | −1.8 (− 7.55–3.9) | 0.5 |
Del | 82.3 ± 15.6 | ||||
RANKL rs9494782 (C > T) | |||||
 Polymorphisms | CC | 92 ± 26.3 | 0.3 | −0.735 (−6.4–5) | 0.8 |
CT | 80 ± 15 | ||||
TT | 84 ± 11 | ||||
 Alleles | C | 84.3 ± 19.4 | 0.8 | −0.85 (−7.55–3.9) | 0.8 |
T | 83.4 ± 11.7 | ||||
RANKL rs2277438 (G > A) | |||||
 Polymorphisms | GG | 74.5 ± 4.5 | 0.03* | 6.5 (1.4–11.6) | 0.02* |
GA | 80 ± 11 | ||||
AA | 87 ± 15 | ||||
 Alleles | A | 85.5 ± 14.5 | 0.1 | −7.97 (−6.8–5.) | 0.1 |
G | 77.6 ± 9 | ||||