Table 1 The relation of the studied polymorphisms and alleles of the RANK/RANKL/OPG axis with the total IQ of TDT children
Gene | TDT total IQ | ||||
|---|---|---|---|---|---|
mean ± SD | p | unstandardized coefficient β (95% CI) | p | ||
OPG rs2073618 (G > C) | |||||
 Polymorphisms | GG | 76.5 ± 11 | 0.2 | 0.84 (−4.33–6) | 0.75 |
GC | 80 ± 11 | ||||
CC | 80 ± 13 | ||||
 Alleles | C | 80 ± 11.8 | 0.84 | −0.5 (−4.8–3.7) | 0.8 |
G | 79.5 ± 10.5 | ||||
RANK rs1805034 (C > T) | |||||
 Polymorphisms | CC | 79.5 ± 3 | 0.03* | −2.4 (− 6.14–1.4) | 0.2 |
CT | 85.4 ± 13 | ||||
TT | 76.8 ± 11.5 | ||||
 Alleles | C | 82 ± 9 | 0.14 | −3.2 (−7.4–1.1) | 0.14 |
T | 78.8 ± 12 | ||||
RANK rs1245811 (A > G) | |||||
 Polymorphisms | AA | 82.5 ± 17 | 0.6 | 0.55 (−4.5–5.6) | 0.8 |
AG | 77 ± 12 | ||||
GG | 80.4 ± 11 | ||||
 Alleles | A | 79.3 ± 13.5 | 0.8 | 0.74 (−5–6.5) | 0.8 |
G | 80 ± 11 | ||||
RANK rs75404003 (C > DEL) | |||||
 Polymorphisms | CC | 81 ± 11 | 0.3 | −2.8 (−7.3–2) | 0.2 |
C DEL | 80 ± 12.5 | ||||
DEL DEL | 73 ± 5.5 | ||||
 Alleles | C | 80.7 ± 11.3 | 0.21 | −3 (−7.6–1.7) | 0.2 |
Del | 77.7 ± 11 | ||||
RANKL rs9494782 (C > T) | |||||
 Polymorphisms | CC | 87 ± 19 | 0.1 | - 0.2 (−4.8–4.45) | 0.95 |
CT | 76 ± 12 | ||||
TT | 80.4 ± 9.5 | ||||
 Alleles | C | 80 ± 15 | 0.94 | −0.18 (−5.05–4.7) | 0.94 |
T | 80 ± 11.3 | ||||
RANKL rs2277438 (G > A) | |||||
 Polymorphisms | GG | 73 ± 5 | 0.2 | 4.15 (−0.14–8.44) | 0.1 |
GA | 78 ± 10 | ||||
AA | 82 ± 12 | ||||
 Alleles | A | 81 ± 11.8 | 0.02* | −5.09 (−9.8 – −3.37) | 0.02* |
G | 76 ± 8.5 | ||||