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Table 2 Preoperative comparisons between survivors and non-survivors to hospital discharge

From: Outcomes of neonatal congenital diaphragmatic hernia in a non-ECMO center in a middle-income country: a retrospective cohort study

Categorical variables

Survival to hospital discharge

p-value

Yes n (%)

No, n (%)

Prenatal diagnosis (n = 120)

26 (32.5)

26 (65.0)

0.001

Inborn (n = 120)

31 (38.8)

28 (70.0)

0.001

Birth lower segment Cesarean section (n = 120)

25 (31.3)

22 (55.0)

0.012

Apgar score at 1 min < 7 (n = 115)

28 (36.8)

28 (71.8)

 < 0.001

Apgar score at 5 min < 7 (n = 115)

12 (15.8)

17 (43.6)

0.001

Response to conventional ventilation (n = 120)

44 (55.0)

2 (5.0)

 < 0.001

Response to HIPPV (n = 49)

14 (60.9)

2 (7.7)

 < 0.001

Response to HFOV (n = 50)

22 (100)

5 (17.9)

 < 0.001

Pulmonary hypertension (n = 119)

50 (62.5)

36 (92.3)

0.001

Pre-operative air leak (n = 114)

7 (9.1)

10 (27.0)

0.012

At surgery (n = 90)

 Low-risk defect (A or B) (n = 88)

69 (88.5)

4 (40.0)

0.001

 Primary repair (n = 90)

68 (85.0)

3(30.0)

0.001

Significant anomaly (n = 119)

9 (11.3)

9 (23.1)

0.091

FiO2 at 24 h < 50% (n = 98)

54 (77.1)

1(3.6)

 < 0.001

Continuous variables

median (IQR)

median (IQR)

 

Birth weight, g (n = 116)

2978 (2650–3260)

2900 (2500–3000)

0.692

Gestational age, weeks (n = 118)

38.3 (37.0–40.0)

38.0 (37.0–40.0)

0.845

Pre-ductal SpO2 at 24 h, % (n = 36)

99.0 (98.0–100.0)

94.0 (90.5–98.5)

0.014

Post-ductal SpO2 at 24 h, % (n = 37)

88.0 (68.0–95.0)

52.0 (91.0–98.0)

 < 0.001

Initial pH (n = 112)

7.3 (7.2–7.5)

7.4 (6.9–7.2)

 < 0.001

Initial pCO2, mmHg (n = 112)

53.5 (40.9–70.7)

74.4 (54.5–112.5)

0.004

Initial pO2, mm Hg (n = 111)

52.1 (41.7–68.6)

39.1 (28.2–59.3)

0.005

  1. FiO2 Fraction of inspired oxygen, HIPPV High-frequency intermittent positive-pressure ventilation, HFOV High-frequency oscillation ventilation, IQR Interquartile range, pCO2 Partial pressure of carbon dioxide, pO2 Partial pressure of oxygen, SpO2 Oxygen saturation, SD Standard deviation