Transcranial doppler as screening method for sickling crises in children with sickle cell anemia: a latin America cohort study

Table 5 Association between the variables analyzed by TCD and vaso-occlusive syndromes in patients with SCA (n = 37)

Variable^a	HR	CI95%	p
TAMMV MCS (cm/s)	1.00	0.99—1.01	0.84
PSV MCA (cm/s)	1.00	0.99—1.01	0.72
EDV MCA (cm/s)	1.02	1.00—1.04	0.08
TAMMV BA (cm/s)	1.00	0.97—1.03	0.85
TAMMV altered	0.46	0.05—4.09	0.48
TAMMV conditional or altered	0.90	0.33—2.43	0.83
Pulsatility Index	0.18	0.01—4.43	0.30

HR Hazard ratio, CI Confidence interval, SCA Sickle cell anemia, TCD Transcranial Doppler, TAMMV Time average mean maximum velocity, MCA Middle cerebral artery, PSV Peak systolic velocity, EDV End-diastolic velocity, BA Basilar artery; ^aMultivariable Survival analyses using a shared frailty model adjusted for sex, genotype, hydroxyurea prescription, prophylactic blood transfusion, hemoglobin, leukocytes, and platelets

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