Table 1 Follow-up TCD Protocol for Stroke Prevention in 2 —6 Year Old SCA Patients

Absence of window

–-

Use another imaging method to analyze the stroke risk

Technical difficulty due to lack of cooperation

–-

Repeat every three months, if possible, by another examiner

Low TAMMV

Less than 70

Repeat after one month, if you continue to use another imaging method to analyze the stroke risk

Normal

Less than 170

Repeat annually

Low conditional

Between 170 and 184

Repeat every three months. In the case of subsequent normal results, the normal group's conduct should be adopted

High conditional

Between 185 and 199

Repeat monthly. In cases of unchanged examinations, it is recommended to repeat every three months. In cases of two atypical examinations, it is recommended to discuss the stroke risk and to consider a chronic transfusion regimen

Abnormal

Greater than or equal to 200— 219

Repeat monthly. If the value remains > 200, it is recommended to discuss the risk of stroke and consider a chronic transfusion regimen. If the result decreases to 170–199, repetition in one month is recommended, if high conditional (between 185 and 199); or in 6 months, if low conditional (between 170 and 184). If the result is normalized (< 170), an annual repetition is recommended

Greater than or equal to 220

Discuss imminent stroke risk and consider a chronic transfusion regimen