Correlation between crown-rump length in the first trimester of pregnancy and neonatal outcomes

BMC Pediatrics

Table 2 Maternal Risk Factors of First-Trimester Variation in Fetal Crown-rump Length Using Univariate and Multivariate Analysis (N = 15,524)

	Univariate analysis				Multivariable analysis
Risk Factor	Effect Size for Fetal Crown to Rump Length (95% CI), mm	P -Value	Effect size of Standard Deviation Score (95% CI)	P -Value	Effect Size for Fetal Crown to Rump Length (95% CI), mm	P -Value	Effect size of Standard Deviation Score (95% CI)	P -Value
Maternal Age	0.24 (0.21 to 0.27)	< .001	0.04 (0.03 to 0.04)	< .001	0.25 (0.22 to 0.28)	< .001	0.04 ( 0.03 to 0.04)	< .001
Pre-pregnancy BMI (kg/m²)	-0.12 (-0.15 to -0.08)	< .001	-0.02 (-0.02 to -0.01)	< .001	-0.17 (-0.21 to -0.13)	< .001	-0.02 (-0.03 to -0.02)	< .001
Multipara (%)	0.71 (0.50 to 0.93)	< .001	0.10 (0.06 to 0.13)	< .001	0.30 (0.08 to 0.52)	0.007	0.04 (0.00 to 0.07)	0.031
Foliate take	0.77 (0.435 to 1.03)	< .001	0.05 (0.00 to 0.09)	0.044	0.78 (0.49 to 1.08)	< .001	0.05 (0.01 to 0.10)	0.019
Vitamin D	0.01 (0.00 to 0.01)	0.019	0.001 (0.000 to 0.002)	0.020	0.003 ( -0.004 to 0.009)	0.404	0.00 (-0.001 to 0.001)	0.742
Family history of diabetes	-0.30 (-0.68 to 0.07)	0.114	-0.04 (-0.10 to 0.02)	0.163	-	-	-	-

We used foetal sex- and gestational age–adjusted linear regression models to assess the associations of each determinant with first trimester CRL separately. We then presented our results as changes per standard deviation score or actual effect size. Subsequently, all the factors associated with CRL were included in the multivariate generalised linear regression model

ISSN: 1471-2431