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Fig. 2 | BMC Pediatrics

Fig. 2

From: Failure of crizotinib based systemic treatment in ALK positive histiocytosis involving the central nervous system: a case report and literature review

Fig. 2

Imaging and pathological results of the case. The MRI of the head shows contrast-enhancing lesions involving the suprasellar region (A-C, blue arrow) and the left temporal lobe (A, red arrow). The lung CT reveals multiple nodes in the right lung (D, green arrow) and the left lung (E, brown arrow). Hematoxylin and eosin staining show an infiltrative proliferation of spindle cells (F). Immunostaining for ALK (G), CD68 (H), and CD163 (I) is positive. ALK rearrangement (green and red signals) is detected in the FISH test (J). The microscopy images was captured by multispectral automatic tissue quantitative scanning and analysis system and ZEISS Fully Automatic Upright Fluorescence Microscope.The measured resolution for images was 360 ppi

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BMC Pediatrics

ISSN: 1471-2431

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