Table 1 Baseline characteristics and outcome data (n=50)

Sex

0.502

 Male

18 (56.2%)

2 (40.0%)

9 (69.2%)

 Female

14 (43.8%)

3 (60.0%)

4 (30.8%)

Birth weight (g)

3161±397

2910±407

3118±377

0.502

Gestational age (week)

39.6±1.0

39.3±0.7

39.4±0.9

0.688

BSID-II MDI

95.06±9.26

74.20±3.27

64.54±3.59

<0.001

BSID-II PDI

94.84±5.89

74.20±3.49

65.08±4.23

<0.001

HIE severity

0.063

 grade I

11 (34.4%)

0 (0%)

4 (30.8%)

 grade II

21 (65.6%)

4 (80.0%)

7 (53.9%)

 grade III

0 (0%)

1 (20.0%)

2 (15.4%)

Apgar score (5 min), median (IQR)

2 (0~3)

2 (1~3)

2 (0~3)

0.673

pH, median (IQR)

7 (6.81-7.25)

7 (6.80-7.15)

7 (6.81-7.19)

0.005

 <7.0, n (%)

13(40.63)

2(40.00)

5(38.46)

0.921

 Intubation or ventilation

18(56.25)

4(80.00)

12(92.31)

0.046

 Chest compression

10(31.25)

3(60.00)

8(61.54)

0.140

 Epinephrine administration

4(12.50)

2(40.00)

6(46.15)

0.030

aEEG (<6 h after birth)

<0.001

 Normal

8 (25.0%)

0 (0%)

0 (0%)

 Abnormal

24 (75.0%)

5 (100%)

13 (100%)

1-day NSE

40.31±7.98

41.74±8.34

40.85±8.92

0.929

3-day NSE

20.52±6.42

39.82±5.92

44.60±9.01

<0.001

Brain MRI

<0.001

 Grade 0

23 (71.9%)

1 (20.0%)

0 (0%)

 Grade 1

7 (21.9%)

0 (0%)

0 (0%)

 Grade 2

2 (6.3%)

0 (0%)

4 (30.8%)

 Grade 3

0 (0%)

2 (40.0%)

4 (30.8%)

 Grade 4

0 (0%)

2 (40.0%)

5 (38.5%)

3-7 days neurologic exam

5(15.63)

2(40.00)

10(76.92)

<0.001