Associations between UGT1A1 and SLCO1B1 polymorphisms and susceptibility to neonatal hyperbilirubinemia in Thai population

Table 3 Correlation between case-control group and genetic factors

Factors	Hyperbilirubinemia group n = 67 (%)	Control group n = 70 (%)	P-value
SLCO1B1 388A > G
AA	1 (20.0)	4 (80.0)	0.173
AG	21 (43.8)	27 (56.3)
GG	45 (53.6)	39 (46.4)
SLCO1B1 521 T > C
TT	57 (54.3)	48 (45.7)	0.041*
TC	9 (31.0)	20 (69.0)
CC	1 (33.3)	2 (66.7)
Combined SLCO1B1
Normal function	57 (54.3)	48 (45.7)	0.041*
Intermediate function	9 (31.0)	20 (69.0)
Low function	1 (33.3)	2 (66.7)
UGT1A1*28
TA6/TA6	49 (54.4)	41 (45.6)	0.097
TA6/TA7	18 (39.1)	28 (60.9)
TA7/TA7	0 (0)	1 (100)
UGT1A1*6211G > A
GG	44 (41.1)	63 (58.9)	< 0.001*
GA	18 (72)	7 (28)
AA	5 (100)	0 (0)
Combined UGT1A1
Wild type	31 (47.0)	35 (53.0)	0.005*
Heterozygous variant	26 (44.1)	33 (55.9)
Homozygous variant	10 (83.3)	2 (16.7)

^a Normal function consists of *1a/*1a, *1a/*1b, *1b/*1b; Intermediate function consists of *1a/*5, *1a/*15, *1b/*15; Low function consists of *5/*5, *5/*15, *15/*15
^b Combined UGT1A1 wild type (*1/*1); heterozygous variant (*1/*28, *1/*6); homozygous variant (*28/*28, *28/*6, *6/*6)
* P-value < 0.05 was considered to be statistically significant

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