BMC Pediatrics

Table 2 Genotype and allele frequency of SLCO1B1 and UGT1A1 variants

From: Associations between UGT1A1 and SLCO1B1 polymorphisms and susceptibility to neonatal hyperbilirubinemia in Thai population

Genetic polymorphism	Allele frequency	Genotype frequency (%)
SLCO1B1 388A > G
A allele	0.21
G allele	0.79
AA		5 (3.6)
AG		48 (35.0)
GG		84 (61.3)
SLCO1B1 521 T > C
T allele	0.87
C allele	0.13
TT		105 (76.6)
TC		29 (21.2)
CC		3 (2.2)
Combined SLCO1B1^a
Normal function		105 (76.6)
Intermediate function		29 (21.2)
Low function		3 (2.2)
UGT1A128*
TA6 allele	0.83
TA7 allele	0.17
TA6/TA6		90 (65.7)
TA6/TA7		46 (33.6)
TA7/TA7		1 (0.7)
UGT1A1*6211G > A
G allele	0.87
A allele	0.13
GG		107 (78.1)
GA		25 (18.2)
AA		5 (3.6)
Combined UGT1A1 ^b
Wild type		66 (48.2)
Heterozygous variant		59 (43.1)
Homozygous variant		12 (8.8)

^a Normal function consists of *1a/*1a, *1a/*1b, *1b/*1b; Intermediate function consists of *1a/*5, *1a/*15, *1b/*15; Low function consists of *5/*5, *5/*15, *15/*15
^b Combined UGT1A1 wild type (*1/*1); heterozygous variant (*1/*28, *1/*6); homozygous variant (*28/*28, *28/*6, *6/*6)

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ISSN: 1471-2431

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