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Table 3 Sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) and 95% confidence intervals (CI) of biomarker combinations to predict sepsis

From: Biomarker combinations in predicting sepsis in hospitalized children with fever

   Sensitivity % (95% CI) Specificity % (95% CI) PPV % (95% CI) NPV % (95% CI)
Model 1 CRP, IL-6 70 (56–81) 83 (74–89) 80 (72–86) 73 (64–80)
Model 2 CRP, sFAS 88 (76–95) 64 (54–73) 71 (65–76) 84 (72–91)
Model 3 CRP, sVCAM-1 83 (70–91) 65 (55–74) 70 (64–75) 79 (67–87)
Model 4 CRP, PCT, IL-6 73 (59–84) 75 (65–83) 75 (67–81) 74 (64–81)
Model 5 CRP, IL-6, sFAS, sVCAM-1 70 (56–81) 84 (75–90) 81 (73–87) 73 (65–81)
Model 6 CRP, PCT, IL-6, sFAS, sVCAM-1 69 (55–80) 82 (72–89) 79 (71–85) 73 (64–80)
Model 7 CRP, PCT, sVCAM-1 69 (56–82) 79 (70–87) 77 (69–84) 72 (63–80)
Model 8 CRP, PCT, sFAS 67 (54–80) 83 (75–91) 81 (72–87) 73 (64–79)
Model 9 IL-6, sFAS, sVCAM-1 53 (40–67) 80 (72–87) 74 (64–81) 64 (56–70)