Table 3 Sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) and 95% confidence intervals (CI) of biomarker combinations to predict sepsis
From: Biomarker combinations in predicting sepsis in hospitalized children with fever
Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | ||
|---|---|---|---|---|---|
Model 1 | CRP, IL-6 | 70 (56–81) | 83 (74–89) | 80 (72–86) | 73 (64–80) |
Model 2 | CRP, sFAS | 88 (76–95) | 64 (54–73) | 71 (65–76) | 84 (72–91) |
Model 3 | CRP, sVCAM-1 | 83 (70–91) | 65 (55–74) | 70 (64–75) | 79 (67–87) |
Model 4 | CRP, PCT, IL-6 | 73 (59–84) | 75 (65–83) | 75 (67–81) | 74 (64–81) |
Model 5 | CRP, IL-6, sFAS, sVCAM-1 | 70 (56–81) | 84 (75–90) | 81 (73–87) | 73 (65–81) |
Model 6 | CRP, PCT, IL-6, sFAS, sVCAM-1 | 69 (55–80) | 82 (72–89) | 79 (71–85) | 73 (64–80) |
Model 7 | CRP, PCT, sVCAM-1 | 69 (56–82) | 79 (70–87) | 77 (69–84) | 72 (63–80) |
Model 8 | CRP, PCT, sFAS | 67 (54–80) | 83 (75–91) | 81 (72–87) | 73 (64–79) |
Model 9 | IL-6, sFAS, sVCAM-1 | 53 (40–67) | 80 (72–87) | 74 (64–81) | 64 (56–70) |