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Table 2 Cutoff values for CRP, PCT and other biomarkers in predicting sepsis, including their sensitivity and specificity, positive predictive value (PPV), negative predictive value (NPV) with 95% confidence intervals

From: Biomarker combinations in predicting sepsis in hospitalized children with fever

Variable Cutoff Value Sensitivity, % (95% CI) Specificity, % (95% CI) PPV % (95% CI) NPV % (95% CI)
CRP, mg/L 69.9 83 (70–91) 65 (55–74) 70 (64–76) 79 (68–87)
PCT, ng/mL 0.43 87 (75–95) 57 (46–67) 67 (62–72) 81 (69–90)
G-CSF, pg/mL 61.58 28 (18–42) 83 (75–90) 62 (48–75) 54 (49–58)
Eotaxin, pg/mL 61.77 51 (37–64) 69 (60–78) 62 (53–71) 59 (51–66)
IFN gamma, pg/mL 8.79 49 (33–65) 73 (62–82) 65 (55–73) 59 (52–66)
IL-10, pg/mL 23.03 51 (36–66) 68 (58–78) 62 (52–70) 58 (51–65)
IL-1ra, pg/mL 213.75 23 (12–38) 93 (86–97) 77 (59–88) 55 (51–59)
IL-6, pg/mL 18.30 86 (74–94) 46 (36–56) 61 (57–66) 77 (62–87)
IL-8, pg/mL 21.90 45 (31–60) 77 (67–85) 66 (56–75) 58 (52–65)
IP-10, pg/mL 569.57 44 (31–58) 74 (65–82) 63 (52–72) 57 (51–63)
MCP-1, pg/mL 673.92 75 (62–86) 37 (27–46) 54 (49–50) 60 (47–71)
PAI-1, pg/mL 135 37 (24–51) 78 (69–85) 63 (51–73) 55 (50–61)
sFAS, pg/mL 2538.29 79 (66–89) 44 (34–53) 58 (52–63) 65 (53–75)
sVCAM-1, pg/mL 868,886.52 83 (70–91) 33 (25–43) 55 (51–60) 66 (51–79)