Table 2 Cutoff values for CRP, PCT and other biomarkers in predicting sepsis, including their sensitivity and specificity, positive predictive value (PPV), negative predictive value (NPV) with 95% confidence intervals
From: Biomarker combinations in predicting sepsis in hospitalized children with fever
Variable | Cutoff Value | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV % (95% CI) | NPV % (95% CI) |
|---|---|---|---|---|---|
CRP, mg/L | 69.9 | 83 (70–91) | 65 (55–74) | 70 (64–76) | 79 (68–87) |
PCT, ng/mL | 0.43 | 87 (75–95) | 57 (46–67) | 67 (62–72) | 81 (69–90) |
G-CSF, pg/mL | 61.58 | 28 (18–42) | 83 (75–90) | 62 (48–75) | 54 (49–58) |
Eotaxin, pg/mL | 61.77 | 51 (37–64) | 69 (60–78) | 62 (53–71) | 59 (51–66) |
IFN gamma, pg/mL | 8.79 | 49 (33–65) | 73 (62–82) | 65 (55–73) | 59 (52–66) |
IL-10, pg/mL | 23.03 | 51 (36–66) | 68 (58–78) | 62 (52–70) | 58 (51–65) |
IL-1ra, pg/mL | 213.75 | 23 (12–38) | 93 (86–97) | 77 (59–88) | 55 (51–59) |
IL-6, pg/mL | 18.30 | 86 (74–94) | 46 (36–56) | 61 (57–66) | 77 (62–87) |
IL-8, pg/mL | 21.90 | 45 (31–60) | 77 (67–85) | 66 (56–75) | 58 (52–65) |
IP-10, pg/mL | 569.57 | 44 (31–58) | 74 (65–82) | 63 (52–72) | 57 (51–63) |
MCP-1, pg/mL | 673.92 | 75 (62–86) | 37 (27–46) | 54 (49–50) | 60 (47–71) |
PAI-1, pg/mL | 135 | 37 (24–51) | 78 (69–85) | 63 (51–73) | 55 (50–61) |
sFAS, pg/mL | 2538.29 | 79 (66–89) | 44 (34–53) | 58 (52–63) | 65 (53–75) |
sVCAM-1, pg/mL | 868,886.52 | 83 (70–91) | 33 (25–43) | 55 (51–60) | 66 (51–79) |