Internal validation and evaluation of the predictive performance of models based on the PRISM-3 (Pediatric Risk of Mortality) and PIM-3 (Pediatric Index of Mortality) scoring systems for predicting mortality in Pediatric Intensive Care Units (PICUs)

Rahmatinejad, Zahra; Rahmatinejad, Fatemeh; Sezavar, Majid; Tohidinezhad, Fariba; Abu-Hanna, Ameen; Eslami, Saeid

doi:10.1186/s12887-022-03228-y

Table 4 Predictive characteristics of PRISM-3 and PIM-3 to predict PICU and in-hospital mortality

From: Internal validation and evaluation of the predictive performance of models based on the PRISM-3 (Pediatric Risk of Mortality) and PIM-3 (Pediatric Index of Mortality) scoring systems for predicting mortality in Pediatric Intensive Care Units (PICUs)

Outcome	Age group	MODEL	AUC 95%CI	Quintiles of risk	Total	Exp	Obs	SMR	HL	BS	Cut-off	Sen	Spe	PPV	NPV	Acc
PICU mortality	Total	PRISM-3	0.831(0.814–0.854)	1:PRISM-3	687	6.97	2	1.34	< 0.001	0.088	6.5	0.881	0.632	0.253	0.974	0.663
	Total	PIM-3	0.745(0.722–0.781)	2:PRISM-3	333	15.01	14		0.014	0.093	2.5	0.700	0.666	0.229	0.940	0.670
	Neonate	PRISM-3	0.841(0.813–0.868)	3:PRISM-3	506	40.31	40		0.118	0.087	6.5	0.878	0.620	0.239	0.974	0.651
	Neonate	PIM-3	0.752(0.710–0.794)	4:PRISM-3	484	60.39	90		0.037	0.091	3.5	0.500	0.837	0.294	0.925	0.797
	Infant	PRISM-3	0.855(0.819–0.891)	5:PRISM-3	436	104.5	158		0.003	0.073	6.5	0.893	0.693	0.250	0.982	0.713
	Infant	PIM-3	0.804(0.752–0.856)	1:PIM-3	391	0	9	1.37	0.071	0.076	4.5	0.595	0.883	0.368	0.950	0.853
	Child	PRISM-3	0.811(0.774–0.849)	2:PIM-3	1127	65.98	82		< 0.001	0.102	7.5	0.846	0.654	0.298	0.960	0.683
	Child	PIM-3	0.736(0.686–0.786)	3:PIM-3	231	21.26	30		0.003	0.107	2.5	0.658	0.675	0.260	0.919	0.672
	Adolescent	PRISM-3	0.697(0.523–0.871)	4:PIM-3	405	52.39	60		0.927	0.144	11.5	0.727	0.574	0.285	0.90	0.603
	Adolescent	PIM-3	0.775(0.614–0.936)	5:PIM-3	292	82.18	123		0.861	0.141	3.5	0.818	0.574	0.310	0.931	0.620
	Hospital A with 1380 patients: AUC for PRISM-3: 0.839(0.808–0.869) with 0.15 Standard Error & AUC for PIM-3: 0.744(0.697–0.790) with 0.24 Standard Error Hospital B with 1404 patients: AUC for PRISM-3: 0.821(0.793–0.850) with 0.14 Standard Error & AUC for PIM-3: 0.743(0.703–0.783) with 0.20 Standard Error
In-hospital mortality	Total	PRISM-3	0.781 (0.759–0.808)	1:PRISM-3	687	6.97	30	1.73	0.068	0.108	6.5	0.785	0.636	0.294	0.939	0.660
	Total	PIM-3	0.737 (0.718–0.771)	2:PRISM-3	333	15.01	28		0.026	0.113	2.5	0.689	0.680	0.293	0.919	0.681
	Neonate	PRISM-3	0.777(0.727–0.827)	3:PRISM-3	506	40.31	49		0.765	0.104	9.5	0.614	0.807	0.354	0.924	0.778
	Neonate	PIM-3	0.753(0.701–0.805)	4:PRISM-3	484	60.39	97		0.183	0.102	2.5	0.644	0.762	0.319	0.925	0.745
	Infant	PRISM-3	0.768(0.719–0.816)	5:PRISM-3	436	104	191		0.299	0.095	6.5	0.744	0.692	0.277	0.945	0.699
	Infant	PIM-3	0.761(0.711–0.811)	1:PIM-3	391	0	16	1.78	0.237	0.099	3.5	0.672	0.725	0.279	0.933	0.718
	Child	PRISM-3	0.775(0.733–0.816)	2:PIM-3	1127	65.98	107		0.034	0.125	7.5	0.773	0.663	0.349	0.926	0.684
	Child	PIM-3	0.726(0.680–0.772)	3:PIM-3	231	21.26	40		0.130	0.129	2.5	0.646	0.690	0.327	0.893	0.681
	Adolescent	PRISM-3	0.822(0.701–0.942)	4:PIM-3	405	52.39	88		0.876	0.188	14	0.684	0.746	0.565	0.828	0.724
	Adolescent	PIM-3	0.840(0.726–0.953)	5:PIM-3	292	82.18	144		0.486	0.197	3.5	0.842	0.666	0.551	0.896	0.724
	Hospital A with 1380 patients: AUC for PRISM-3: 0.784 (0.747–0.821) with 0.19 Standard Error & AUC for PIM-3: 0.725(0.681–0.769) with 0.23 Standard Error Hospital B with 1404 patients: AUC for PRISM-3: 0.773(0.740–0.805) with 0.17 Standard Error & AUC for PIM-3: 0.740 (0.705–0.775) with 0.18 Standard Error

Abbreviations: SMR standardized mortality ratio, Exp expected mortality, Obs observed mortality, HL Hosmer–Lemeshow, BS Brier Score, Sen Sensitivity, Spe Septicity, PPV Positive predictive value, NPV Negative predictive value, Acc Accuracy, PRISM Pediatric Risk of Mortality, PIM Pediatric Index of Mortality

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ISSN: 1471-2431

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