“Association of MTHFR and MS/MTR gene polymorphisms with congenital heart defects in North Indian population (Jammu and Kashmir): a case–control study encompassing meta-analysis and trial sequential analysis”

Table 9 Overall meta-analysis and subgroup analysis by ethnicity for MS A2756G polymorphism

Genetic Model	Number of studies	Test of association			Heterogeneity				Egger's test p- value
Genetic Model	Number of studies	OR	95% CI	p-value	Model	p-value		I^2	Egger's test p- value
Overall
Allele contrast (G vs. A)	6	1.05	0.88–1.26	0.6	Fixed	0.3		0.1993	0.4631
Recessive model (GG vs. AG + AA)	6	1.11	0.47–2.64	0.8	Random	0.07		0.5136	0.5171
Dominant model (GG + AG vs. AA)	6	1.08	0.86–1.35	0.5	Fixed	0.6		0	0.7422
Homozygous model (GG vs AA)	6	0.95	0.57–1.56	0.8	Fixed	0.1		0.4122	0.4344
Heterozygous model (GG vs AG)	6	1.10	0.45–2.72	0.8	Random	0.06		0.5204	0.5685
Caucasians
Allele contrast (G vs. A)	3	0.95	0.75–1.19	0.6	Fixed	0.5		0	0.9501
Recessive model (GG vs. AG + AA)	3	0.86	0.30–2.47	0.8	Random	0.03		0.7067	0.9516
Dominant model (GG + AG vs. AA)	3	0.96	0.71–1.31`	0.8	Fixed	0.92		0	0.0379
Homozygous model (GG vs AA)	3	0.84	0.34–2.06	0.7	Random	0.1		0.5605	0.9324
Heterozygous model (GG vs AG)	3	0.87	0.26–2.91	0.82	Random	0.02		0.7476	0.9915
Asians
Allele contrast (G vs. A)	3	1.25	0.93–1.69	0.1	Fixed	0.3	0.2455		0.6974
Recessive model (GG vs. AG + AA)	3	2.26	0.51–9.94	0.3	Fixed	0.4	0.0104		0.5599
Dominant model (GG + AG vs. AA)	3	1.24	0.89–1.73	0.21	Fixed	0.3	0.0785		0.5501
Homozygous model (GG vs AA)	3	2.42	0.55–10.69	0.2	Fixed	0.3	0.1005		0.577
Heterozygous model (GG vs AG)	3	1.95	0.43–8.78	0.4	Fixed	0.5	0		0.4763

ISSN: 1471-2431