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Table 2 Characteristics between survivors and non-survivors

From: Mortality reduction in pediatric patients with severe fatal human adenoviral pneumonia treated with high titer neutralizing antibodies (NAbs) plasma: a retrospective cohort study

Variables

Survivors

N = 42

Non-survivors

N = 17

p value

Age (months)

17.5 (7.75–30.00)

21.00 (10.00–52.50)

0.344

Male, n (%)

28 (66.7)

12 (70.6)

0.770

Weight (kg)

10.00 (9.38–12.50)

11.00 (9.00–17.50)

0.400

Fever daysa

9.50 (7.00–14.25)

11.00 (8.00–15.50)

0.563

Co-infection, n (%)

13 (31.0)

4 (23.5)

0.408

Blood routine and infection indicators

 Leukocyte,109/L

5.55 (2.70–9.23)

6.30 (2.60–11.50)

0.960

 Hemoglobin,(g/L)

92.26 ± 16.62

91.35 ± 19.63

0.857

 Neutrophil, 109/L

3.91 (1.56–6.78)

3.00 (1.11–10.15)

0.867

 Platelets, 109/L

195.50 (132.75–302.25)

242.00 (67.50–356.00)

0.947

 C reactive protein, mg/L

37.40 (11.66–73.35)

27.52 (9.44–55.00)

0.808

Organ function indicators, n (%)

 Alanine transaminase>50 U/L

9 (21.4)

7 (41.2)

0.122

 Creatinin>62 umol/L

0 (0.0)

1 (5.9)

0.288

 Creatine kinase isoenzyme>37 U/L

13 (31.0)

8 (47.1)

0.242

 Prothrombin time>15 s

6 (14.3)

5 (29.4)

0.162

 Activated partial prothrombin time>45 s

18 (42.9)

10 (58.8)

0.266

 Fibrinogen<2 g/L

9 (21.4)

6 (35.3)

0.216

Severity of Illness, n (%)

 SOFA score ≥ 7

18 (42.9)

15 (88.2)

0.001

 OI ≥ 8

22 (52.4)

13 (76.5)

0.088

Treatment, n (%)

 Human immunoglobulin

38 (90.5)

14 (82.4)

0.320

 Glucocorticoid

27 (64.3)

8 (47.1)

0.222

 Vasoactive drug

23 (54.8)

13 (76.5)

0.122

 High titer NAbs plasma

27 (64.3)

6 (35.3)

0.042

Adenovirus genotype, n (%)

 ADV3

4 (9.5)

1 (5.9)

0.578

 ADV7

36 (85.7)

16 (94.1)

 

 Unkown

2 (4.8)

0 (0)

 
  1. SOFA Sequential organ failure assessment, OI Oxygen index, ADV Adenovirus, NAbs Neutralizing antibodies
  2. Fever daysa: Fever days before adenovirus genotype determined