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Table 2 Risk factors to develop BI in patients with acute bronchiolitis

From: Risk factors and incidence of invasive bacterial infection in severe bronchiolitis: the RICOIB prospective study

Risk factor

No BI

(n = 500)

CA-BI

(n = 118)

HAI

(n = 57)

P1

P2

P3

Male gendera

303 (60.6)

64 (54.2)

32 (56.1)

0.206

0.813

0.515

Age in daysb

57 (27–109)

42 (25–92)

46 (24–74)

0.728

0.721

0.475

 < 3 months of agea

355 (71)

87 (73.7)

45 (78.9)

0.555

0.452

0.206

Previous comorbiditiesa

165 (33)

32 (27.1)

25 (43.9)

0.218

0.027

0.101

Comorbidity’s typesa

 Prematurity

119 (23.8)

23 (19.5)

17 (29.8)

0.317

0.127

0.316

 Respiratory

18 (3.6)

1 (0.8)

1 (1.8)

0.119

0.547

0.709

 Cardiologic

37 (7.4)

8 (6.8)

7 (12.3)

0.816

0.223

0.196

 Neurological

10 (2.0)

4 (3.4)

2 (3.5)

0.361

1.000

0.352

 Others

24 (4.8)

6 (5.1)

6 (10.5)

0.897

0.182

0.070

 BROSJOD#

9 (7–11)

10 (8–12)

10 (7.3–11)

 < 0.001

0.184

0.296

 BROSJOD > 12a

36 (7.5)

20 (19.8)

5 (10.4)

 < 0.001

0.152

0.480

 PRISM scaleb

3 (0–6)

3 (0–6)

3 (0–6)

 < 0.001

0.513

 < 0.001

Viral etiologya

 RSV

336 (67.2)

80 (67.8)

29 (50.9)

0.901

0.030

0.014

 Rhino/Enterovirus

121 (24.2)

27 (22.9)

14 (24.6)

0.763

0.806

0.952

 Metapneumovirus

21 (4.2)

5 (4.2)

1 (1.8)

0.986

0.665

0.716

 Influenza

26 (5.2)

3 (2.5)

3 (5.3)

0.219

0.393

1.000

 Viral co-infectiona

119 (23.8)

23 (19.5)

8 (14)

0.317

0.376

0.096

 Bacterial co-infectiona

-

13 (11)

4 (7)

-

0.587

-

Received treatmenta

 Nebulized treatment

411 (82.2)

94 (79.7)

43 (75.4)

0.521

0.525

0.213

 Endotracheal mucolytics

40 (8)

25 (21.2)

17 (29.8)

 < 0.001

0.210

 < 0.001

 Central linea

110 (22)

67 (56.8)

34 (59.6)

 < 0.001

0.719

 < 0.001

 Central line, daysb

9 (7–12.5)

8 (6.3–11)

11.8 (7.3–19)

0.453

0.001

0.003

 Urinary cathetera

134 (26.8)

65 (55.1)

39 (68.4)

 < 0.001

0.092

 < 0.001

 Urinary catheter, daysb

8.5 (6.3–10.9)

7.8 (6–10.5)

11 (7.1–16.5)

0.976

0.001

0.001

  1. Comparisons made: P1: no BI vs. CA-BI; P2: CA-BI vs. HAI; P3: no BI vs. HAI
  2. BI invasive bacterial infection, CA-BI community-acquired invasive bacterial infection, HAI hospital-acquired infection, PRISM Pediatric Risk Score of Mortality III scale, CMV conventional mechanical ventilation
  3. aCategorical variable, expressed as frequency (%), and compared using Chi-square test
  4. bContinuous variable, expressed as median (interquartile range), and compared using the Mann–Whitney test.