Table 2 The relationship between treatment outcome and proteinuria before RTX administration and renal pathology in pediatric patients with NS

SDNS (p = 0.145)

Nephrotic

5 (38.5%)

0 (0.0%)

0 (0.0%)

5 (19.2%)

Sub-nephrotic

4 (30.8%)

2 (50.0%)

6 (66.7%)

12 (46.2%)

Physiologic

4 (30.8%)

2 (50.0%)

3 (33.3%)

9 (34.6%)

Total

13 (100%)

4 (100%)

9 (100%)

26 (100%)

SRNS (p = 0.005)

Nephrotic

1 (20.0%)

0 (0.0%)

0 (0.0%)

1 (4.5%)

Sub-nephrotic

0 (0.0%)

0 (0.0%)

6 (66.7%)

6 (27.3%)

Physiologic

4 (80.0%)

8 (100%)

3 (33.3%)

15 (68.2%)

Total

5 (100%)

8 (100%)

9 (100%)

22 (100%)

SDNS+SRNS (p = 0.001)

Nephrotic

6 (33.3%)

0 (0.0%)

0 (0.0%)

6 (12.5%)

Sub-nephrotic

4 (22.2%)

2 (16.7%)

12 (66.7%)

18 (37.5%)

Physiologic

8 (44.4%)

10 (83.3%)

6 (33.3%)

24 (50.0%)

Total

18 (100%)

12 (100%)

18 (100%)

48 (100%)

NS type

Renal pathology^a

Total

Complete remission

No response

Partial remission

SDNS (p = 0.113)

MCNS

3 (23.1%)

1 (25.0%)

0 (0.0%)

4 (15.4%)

DMP

9 (69.2%)

1 (25.0%)

8 (88.9%)

18 (69.2%)

FSGS

1 (7.7%)

2 (50.0%)

1 (11.1%)

4 (15.4%)

MGN

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

Total

13 (100%)

4 (100%)

9 (100%)

26 (100%)

SRNS (p = 0.047)

MCNS

1 (20.0%)

0 (0.0%)

0 (0.0%)

1 (4.5%)

DMP

1 (20.0%)

1 (12.5%)

7 (77.8%)

9 (40.9%)

FSGS

3 (60.0%)

6 (75.0%)

2 (22.2%)

11 (50.0%)

MGN

0 (0.0%)

1 (12.5%)

0 (0.0%)

1 (4.5%)

Total

5 (100%)

8 (100%)

9 (100%)

22 (100%)

SDNS+SRNS (p = 0.003)

MCNS

4 (22.2%)

1 (8.3%)

0 (0.0%)

5 (10.4%)

DMP

10 (55.6%)

2 (16.7%)

15 (83.3%)

27 (56.2%)

FSGS

4 (22.2%)

8 (66.7%)

3 (16.7%)

15 (31.2%)

MGN

0 (0.0%)

1 (8.3%)

0 (0.0%)

1 (2.1%)

Total

18 (100%)

12 (100%)

18 (100%)

48 (100%)